Document Detail

Dental risk factors for osteonecrosis of the jaws: a CONDOR case-control study.
MedLine Citation:
PMID:  23212125     Owner:  NLM     Status:  Publisher    
BACKGROUND: Reports of osteonecrosis of the jaw (ONJ) have associated this lesion to treatment with bisphosphonates (BPs) and dental procedures. In this study, we investigated the association of specific dental diagnoses and procedures with ONJ among patients with past BP use. METHODS: Dentists from three practice-based research networks provided ONJ cases and controls (1:3). Data gathered from patients and dental offices with two respective standard questionnaires included demographic, medical, pharmaceutical, and dental information. Diagnoses and procedures up to 3 years prior to ONJ (prior to interview for controls) were analyzed within risk strata, defined by BP use and cancer status, using interaction terms within conditional logistic regression models. RESULTS: We enrolled 191 ONJ cases and 573 controls from 119 dental offices. Among participants who had used only oral BP, extraction was the only dental risk factor for ONJ (odds ratio (OR) = 12, p = 0.01). Suppuration was also more prevalent in cases (18 %) than in controls (9 %), but not statistically significant (OR = 9, p = 0.06). Among participants who had not used either oral or IV BP (a majority of whom received radiation therapy to the head and neck), suppuration was the only dental risk factor for ONJ (prevalence = 34 % for cases and 8 % for controls; OR = 7, p = 0.01). The prevalence of extractions in this group was also higher, but not statistically significant (44 vs 10 %; OR = 3). Limited power precludes definitive findings among participants exposed to IV BP. CONCLUSIONS: Among patients taking oral BP, extraction was the only dental procedure associated with subsequent ONJ development CLINICAL RELEVANCE: Results of this study suggest that routine dental procedures are not associated with development of ONJ in patients exposed to BPs.
A Barasch; J Cunha-Cruz; F Curro; T Derouen; G H Gilbert; P Hujoel; M M Safford; D A Vena; A E Voinea-Griffin; H Wu;
Related Documents :
24113955 - Summary of: permanent dentition caries through the first half of life.
23960495 - Dental patients' awareness and knowledge in using dental implants as an option in repla...
24993265 - Understanding the chemistry of dental erosion.
24453445 - Dental aesthetic index of school students in telangana region - an epidemiological study.
24717755 - Behavior guidance symposium workshop b report - training implications.
11109575 - Freud comes to palestine. a study of psychoanalysis in a cultural context.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-2
Journal Detail:
Title:  Clinical oral investigations     Volume:  -     ISSN:  1436-3771     ISO Abbreviation:  Clin Oral Investig     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9707115     Medline TA:  Clin Oral Investig     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Dental Medicine, Winthrop University Hospital, 222 Station Plaza N, Suite 408, Mineola, NY, 11501, USA,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Optical diffusion performance of nanophosphor-based materials for use in medical imaging.
Next Document:  Soy peptides enhance yeast cell growth at low temperatures.