Document Detail

Dental and periodontal history of oncologic patients on parenteral bisphosphonates with or without osteonecrosis of the jaws: a pilot study.
MedLine Citation:
PMID:  18801674     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We tested the hypothesis that patients on bisphosphonates with ONJ might have a poorer dental and periodontal history than non-ONJ patients. Our aim was to retrospectively compare medical and oral history of patients on bisphosphonates with and without ONJ. STUDY DESIGN: A total of 39 oncologic patients on bisphosphonates were interviewed, examined, and had a panoramic radiograph taken. DMFT values and residual bone levels were calculated and compared for ONJ and non-ONJ patients. RESULTS: Twenty of 39 patients had ONJ. No statistical differences in caries or residual bone level as well as dental extractions were detected, although twice as many patients with ONJ underwent dental extractions. ONJ patients had received statistically more administrations of bisphosphonates compared to non-ONJ patients. CONCLUSION: A long history of bisphosphonate administration might represent a risk for ONJ onset.
Daniela Carmagnola; Silvio Celestino; Silvio Abati
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Publication Detail:
Type:  Journal Article     Date:  2008-09-17
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  106     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e10-5     Citation Subset:  D; IM    
Department of Medicine, University of Milan, Italy.
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MeSH Terms
Aged, 80 and over
Alveolar Bone Loss / pathology
Antineoplastic Agents / administration & dosage,  adverse effects*
Bone Density Conservation Agents / administration & dosage,  adverse effects*
DMF Index
Diphosphonates / administration & dosage,  adverse effects*
Imidazoles / administration & dosage,  adverse effects*
Jaw Diseases / chemically induced*
Middle Aged
Neoplasms / drug therapy
Osteonecrosis / chemically induced*
Periodontal Index
Pilot Projects
Retrospective Studies
Risk Factors
Stomatitis, Denture / complications
Tooth Extraction / adverse effects
Reg. No./Substance:
0/Antineoplastic Agents; 0/Bone Density Conservation Agents; 0/Diphosphonates; 0/Imidazoles; 118072-93-8/zoledronic acid

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