| Dental abnormalities in patients with familial hypophosphatemic vitamin D-resistant rickets: prevention by early treatment with 1-hydroxyvitamin D. | |
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MedLine Citation:
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PMID: 12640383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the dental effects of 1-hydroxylated vitamin D3 treatment in patients with familial hypophosphatemic vitamin D-resistant rickets. Study design Forty-eight children and adult patients were included in the study; 16 had received no treatment or phosphate supplements with vitamin D/25-(OH) D3 before puberty. The 32 younger ones had received phosphate supplements with 1alpha-(OH)D3 from infancy. All patients were clinically examined, and panoramic and periapical radiographs were made. Evaluations of decayed, missing, or filled teeth and decayed or filled teeth indexes and of pulp ratios allowed comparison with healthy age-matched control patients. RESULTS: Poor dental health and characteristic dental anomalies were found in the 16 older patients. In contrast, the 32 younger patients had a normal dental status as regards reference ranges in healthy age-matched populations, although they still showed prominent pulp horns on deciduous teeth and increased pulp area/tooth area ratios. CONCLUSIONS: This investigation shows the beneficial effects of 1alpha-(OH)D3 treatment on the dental status of vitamin D-resistant rickets patients and emphasizes the necessity of early treatment. Remaining defects may result from early exposure of odontoblasts and surrounding osteoblasts to hypophosphatemia, before the commencement of treatment, and/or from intrinsic cell disturbances linked to the genetic alteration(s). |
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Authors:
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Catherine Chaussain-Miller; Christiane Sinding; Maryse Wolikow; Jean-Jacques Lasfargues; Gaston Godeau; Michèle Garabédian |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 142 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-17 Completed Date: 2003-04-10 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 324-31 Citation Subset: AIM; IM |
Affiliation:
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Conservative Dentistry and Endodontics Department, Dental School of University of Paris 5, and CNRS (UMR-8104), St Vincent de Paul Hospital, Paris, France. miller@odontologie.univ-paris5-fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Calcitriol / therapeutic use* Child Child, Preschool DMF Index Female Humans Hypophosphatemia, Familial / complications, drug therapy* Male Middle Aged Radiography, Panoramic Tooth Abnormalities / complications, prevention & control* Tooth Diseases / complications, prevention & control* |
| Chemical | |
Reg. No./Substance:
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32222-06-3/Calcitriol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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