| Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging. | |
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MedLine Citation:
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PMID: 310864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rate of capping and shedding of cross-linked surface immunoglobulins (SIg) was slower in old Lewis rats (greater than 24 mo) than in young Lewis rats (3-4 mo). Analysis of spleen cell populations with the fluorescence-activated cell sorter indicated that with aging there was a loss of cells with a high density of SIg. Cells with the highest density of SIg capped and shed cross-linked SIg faster than cells with a low density of SIg. The alteration in density of SIg may account for the difference in capping kinetics. Colchicine treatment increased the rate of capping of lymphocytes from young animals, but had no effect on the capping kinetics of lymphocytes from old animals. |
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Authors:
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B A Woda; J D Feldman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 149 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1979 Feb |
Date Detail:
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Created Date: 1979-04-28 Completed Date: 1979-04-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 416-23 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Animals B-Lymphocytes / immunology* Colchicine / pharmacology Endocytosis Female Immunologic Capping* / drug effects Male Rats Rats, Inbred Lew Receptors, Antigen, B-Cell / metabolism* Spleen / immunology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Antigen, B-Cell; 64-86-8/Colchicine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Print publication date: Day: 1 Month: 2 Year: 1979 Volume: 149 Issue: 2 First Page: 416 Last Page: 423 ID: 2184810 Publisher Id: 79110989 PubMed Id: 310864 |
| Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging | |
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