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Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging.
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MedLine Citation:
PMID:  310864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rate of capping and shedding of cross-linked surface immunoglobulins (SIg) was slower in old Lewis rats (greater than 24 mo) than in young Lewis rats (3-4 mo). Analysis of spleen cell populations with the fluorescence-activated cell sorter indicated that with aging there was a loss of cells with a high density of SIg. Cells with the highest density of SIg capped and shed cross-linked SIg faster than cells with a low density of SIg. The alteration in density of SIg may account for the difference in capping kinetics. Colchicine treatment increased the rate of capping of lymphocytes from young animals, but had no effect on the capping kinetics of lymphocytes from old animals.
Authors:
B A Woda; J D Feldman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  149     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-04-28     Completed Date:  1979-04-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  416-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging*
Animals
B-Lymphocytes / immunology*
Colchicine / pharmacology
Endocytosis
Female
Immunologic Capping* / drug effects
Male
Rats
Rats, Inbred Lew
Receptors, Antigen, B-Cell / metabolism*
Spleen / immunology
Chemical
Reg. No./Substance:
0/Receptors, Antigen, B-Cell; 64-86-8/Colchicine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 2 Year: 1979
Volume: 149 Issue: 2
First Page: 416 Last Page: 423
ID: 2184810
Publisher Id: 79110989
PubMed Id: 310864

Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging


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