| Density of microvessels positive for CD105 (endoglin) is related to prognosis in meningiomas. | |
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MedLine Citation:
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PMID: 17594108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microvessel density (MVD) is considered to be a prognostic marker in many tumours. Nevertheless, conflicting results were achieved regarding its prognostic role in meningiomas when it was quantified through pan-endothelial markers such as CD34, CD31 or Factor VIII. In the present study, MVD was assessed in meningiomas through the specific marker for neo-angiogenesis CD105. Fifty-four formalin fixed, paraffin embedded, surgical cases of meningiomas (WHO 28 grade I and 26 grade II) as well as ten normal leptomeningeal samples were submitted to immunohistochemical analysis for CD105. CD34 immuno-expression was also evaluated on consecutive parallel sections. For each case, MVD was estimated in terms of number of vessels/mm(2). CD105 was not evidenced in normal samples, whereas it was demonstrated in the vessels within 14/28 WHO grade I cases and within 24/26 WHO grade II meningiomas. On the contrary, CD34 antibody stained blood vessels in both normal and neoplastic samples; moreover, in each case, it stained more microvessels than CD105 antibody (25.33 +/- 21.16 vs. 50.72 +/- 26.75). Higher CD105 counts were significantly correlated with higher histological grade and Ki-67 LI > 4%. No statistical significant correlations were encountered between MVD measured by either CD105 and CD34 and sex, age, site of tumour or extent of surgical resection. CD105-MVD, but not CD34-MVD, showed an inverse significant correlation with overall survival and recurrence-free survival. In conclusion, our study suggests the higher specificity of CD105 in comparison to pan-endothelial markers in the evaluation of meningioma neo-angiogenesis, and its higher prognostic significance. CD105 might serve as a target for therapeutic approaches blocking blood supply in meningiomas. |
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Authors:
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Valeria Barresi; Serenella Cerasoli; Enrica Vitarelli; Giovanni Tuccari |
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Publication Detail:
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Type: Journal Article Date: 2007-06-27 |
Journal Detail:
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Title: Acta neuropathologica Volume: 114 ISSN: 0001-6322 ISO Abbreviation: Acta Neuropathol. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-13 Completed Date: 2007-11-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0412041 Medline TA: Acta Neuropathol Country: Germany |
Other Details:
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Languages: eng Pagination: 147-56 Citation Subset: IM |
Affiliation:
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Dipartimento di Patologia Umana, University of Messina, Messina, Italy. valeriabarresi@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antigens, CD / metabolism* Antigens, CD34 / metabolism Capillaries Female Humans Immunohistochemistry Kaplan-Meiers Estimate Male Meningeal Neoplasms / blood supply, metabolism, pathology* Meningioma / blood supply, metabolism, pathology* Middle Aged Neovascularization, Pathologic / metabolism, pathology* Prognosis Receptors, Cell Surface / metabolism* Sensitivity and Specificity Tumor Markers, Biological / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD34; 0/ENG protein, human; 0/Receptors, Cell Surface; 0/Tumor Markers, Biological |
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