Document Detail


Density of microvessels positive for CD105 (endoglin) is related to prognosis in meningiomas.
MedLine Citation:
PMID:  17594108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microvessel density (MVD) is considered to be a prognostic marker in many tumours. Nevertheless, conflicting results were achieved regarding its prognostic role in meningiomas when it was quantified through pan-endothelial markers such as CD34, CD31 or Factor VIII. In the present study, MVD was assessed in meningiomas through the specific marker for neo-angiogenesis CD105. Fifty-four formalin fixed, paraffin embedded, surgical cases of meningiomas (WHO 28 grade I and 26 grade II) as well as ten normal leptomeningeal samples were submitted to immunohistochemical analysis for CD105. CD34 immuno-expression was also evaluated on consecutive parallel sections. For each case, MVD was estimated in terms of number of vessels/mm(2). CD105 was not evidenced in normal samples, whereas it was demonstrated in the vessels within 14/28 WHO grade I cases and within 24/26 WHO grade II meningiomas. On the contrary, CD34 antibody stained blood vessels in both normal and neoplastic samples; moreover, in each case, it stained more microvessels than CD105 antibody (25.33 +/- 21.16 vs. 50.72 +/- 26.75). Higher CD105 counts were significantly correlated with higher histological grade and Ki-67 LI > 4%. No statistical significant correlations were encountered between MVD measured by either CD105 and CD34 and sex, age, site of tumour or extent of surgical resection. CD105-MVD, but not CD34-MVD, showed an inverse significant correlation with overall survival and recurrence-free survival. In conclusion, our study suggests the higher specificity of CD105 in comparison to pan-endothelial markers in the evaluation of meningioma neo-angiogenesis, and its higher prognostic significance. CD105 might serve as a target for therapeutic approaches blocking blood supply in meningiomas.
Authors:
Valeria Barresi; Serenella Cerasoli; Enrica Vitarelli; Giovanni Tuccari
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Publication Detail:
Type:  Journal Article     Date:  2007-06-27
Journal Detail:
Title:  Acta neuropathologica     Volume:  114     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-13     Completed Date:  2007-11-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  147-56     Citation Subset:  IM    
Affiliation:
Dipartimento di Patologia Umana, University of Messina, Messina, Italy. valeriabarresi@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antigens, CD / metabolism*
Antigens, CD34 / metabolism
Capillaries
Female
Humans
Immunohistochemistry
Kaplan-Meiers Estimate
Male
Meningeal Neoplasms / blood supply,  metabolism,  pathology*
Meningioma / blood supply,  metabolism,  pathology*
Middle Aged
Neovascularization, Pathologic / metabolism,  pathology*
Prognosis
Receptors, Cell Surface / metabolism*
Sensitivity and Specificity
Tumor Markers, Biological / analysis*
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD34; 0/ENG protein, human; 0/Receptors, Cell Surface; 0/Tumor Markers, Biological

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