Document Detail


Density of beta adrenoceptors in rat heart and lymphocytes 48 hours and 7 days after acute myocardial infarction.
MedLine Citation:
PMID:  2559805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Down regulation of the beta adrenoceptor is thought to play an important role in the diminished response to catecholamines in heart failure. beta Adrenoceptor densities were measured on membrane homogenates of rat right ventricle and lymphocytes 48 h or 7 d after experimental myocardial infarction, and in rats exposed to a continuous infusion of isoprenaline (400 micrograms.kg-1.h1). The performance of the rat hearts was also evaluated 48 h post infarction in an isolated retrograde perfused heart preparation. In contrast to a 60% down regulation in right ventricle and a 20% down regulation in lymphocyte membranes after isoprenaline infusion, there was no change in right ventricle and lymphocyte beta adrenoceptor densities after myocardial infarction. Left ventricular contractile performance was significantly depressed 48 h after myocardial infarction. Mean basal left ventricular pressure decreased from 108(SEM 3) to 63(4) mm Hg while the maximal response to dobutamine was decreased from 204(4) to 105(12) mm Hg (n = 8). No correlation was found between the receptor densities of right ventricular and lymphocyte membranes. We conclude that diminished response to beta sympathomimetics after myocardial infarction cannot be attributed to a loss of surface beta adrenoceptors, and that the lymphocyte beta adrenoceptor does not provide an adequate system to monitor small receptor changes on the myocardium.
Authors:
W Vleeming; P A van der Wouw; J D te Biesebeek; H H van Rooij; J Wemer; A J Porsius
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  23     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-03-21     Completed Date:  1990-03-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  859-66     Citation Subset:  IM    
Affiliation:
Department of Pharmacotherapy, Faculty of Pharmacy, University of Utrecht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane / analysis
Dobutamine / pharmacology
Heart / drug effects,  physiopathology
Heart Ventricles / analysis,  ultrastructure
Isoproterenol / pharmacology
Lymphocytes / analysis*,  ultrastructure
Male
Myocardial Infarction / metabolism*,  physiopathology
Myocardium / analysis*,  ultrastructure
Pindolol / analogs & derivatives,  metabolism
Rats
Rats, Inbred Strains
Receptors, Adrenergic, beta / analysis*,  drug effects,  metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 13523-86-9/Pindolol; 34368-04-2/Dobutamine; 7683-59-2/Isoproterenol; 76875-01-9/3-iodopindolol

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