Document Detail

Densitometric measurement of increased endothelial permeability in arteriosclerotic plaques and inhibition of permeability under the influence of two calcium antagonists.
MedLine Citation:
PMID:  2712859     Owner:  NLM     Status:  MEDLINE    
A densitometric technique was established to investigate quantitative changes in endothelial permeability for horseradish peroxidase (HRP), mol. wt. 40,000 daltons, in rabbit carotid artery. Repeated weak electrical stimulations of rabbit carotid arterial walls with implanted electrodes lead to fibromuscular plaques mainly beneath the anode. It could be demonstrated that there exists a typical growth curve of the plaques dependent on the number of days of electrostimulation, with a fast proliferation rate of smooth muscle cells in the first 2 weeks of electrostimulation, and an increasing retardation of proliferation during the next 4 weeks. Endothelial permeability for HRP increases in close relation to the plaque development. Intravenous applications of single doses of the calcium entry blockers flunarizine or nimodipine are able to inhibit the increased permeability of the endothelial lining covering arteriosclerotic plaques. The intensity of the inhibitory action of these calcium antagonists correlates with the size of the arteriosclerotic plaques in inverse proportion, but nevertheless in large plaques an inhibitory effect is seen.
T Strohschneider; E Betz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  75     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-06-06     Completed Date:  1989-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  135-44     Citation Subset:  IM    
Institute of Physiology I, University of Tübingen, F.R.G.
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MeSH Terms
Arteriosclerosis / metabolism*,  pathology
Capillary Permeability
Carotid Arteries / metabolism,  pathology
Densitometry / methods
Electric Stimulation
Endothelium, Vascular / metabolism*,  pathology
Flunarizine / pharmacology*
Horseradish Peroxidase / pharmacokinetics
Nimodipine / pharmacology*
Reg. No./Substance:
52468-60-7/Flunarizine; 66085-59-4/Nimodipine; EC 1.11.1.-/Horseradish Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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