Document Detail

Dense Pattern of Embryonal Rhabdomyosarcoma, a Lesion Easily Confused With Alveolar Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group.
MedLine Citation:
PMID:  23765537     Owner:  NLM     Status:  In-Data-Review    
Objectives: To examine whether the frequency of fusion-negative alveolar rhabdomyosarcoma (ARMSn) increased coincident with changes in the definition of alveolar histology. Methods: We re-reviewed alveolar rhabdomyosarcoma (ARMS) in the Children's Oncology Group study D9803, comparing histopathology with fusion status. Results: Our review of 255 original ARMS cases (compared with a control group of 38 embryonal rhabdomyosarcomas [ERMS] cases) revealed that many had an ARMS-like densely cellular pattern with cytologic features and myogenin expression more typical of ERMS. Following re-review, 84 (33%) cases of original ARMS were rediagnosed as ERMS. All reclassified ERMS, including dense ERMS, were fusion negative, whereas 82% of confirmed ARMS cases were fusion positive. Total ARMS diagnoses returned to historic rates of 25% to 30% of all rhabdomyosarcomas, and ARMSn decreased from 37% to 18% of ARMS cases. The outcome of reclassified ERMS was similar to confirmed ERMS. Conclusions: To address the role of fusion status in risk stratification, pathologists should include both a histologic diagnosis and an evaluation of fusion status for all new ARMS diagnoses.
Erin R Rudzinski; Lisa A Teot; James R Anderson; Julie Moore; Julia A Bridge; Frederic G Barr; Julie M Gastier-Foster; Stephen X Skapek; Douglas S Hawkins; David M Parham
Related Documents :
23437407 - Use of expansion factors to estimate the burden of dengue in southeast asia: a systemat...
22962387 - Scorpion sting: eclampsia.
7884197 - Posterior sternoclavicular dislocation: a case report.
23027707 - Methodologies for the detection of adverse drug reactions: comparison of hospital datab...
2941217 - Allergic contact dermatitis due to a biocide containing 5-chloro-2-methyl-4-isothiazoli...
16307327 - Localized primary amyloidosis of the prostate, bladder and ureters.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  140     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  82-90     Citation Subset:  AIM; IM    
Seattle Children's Hospital, Department of Laboratories, M/S OC.8.720, 4800 Sandpoint Way NE, Seattle, WA 98015;
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Low RIN1 Expression in HCC Is Associated With Tumor Invasion and Unfavorable Prognosis.
Next Document:  Histologic findings of femoral heads from patients with Gaucher disease treated with enzyme replacem...