Document Detail

Densanins A and B, New Macrocyclic Pyrrole Alkaloids Isolated from the Marine Sponge Haliclona densaspicula.
MedLine Citation:
PMID:  23211017     Owner:  NLM     Status:  Publisher    
Densanins A (1) and B (2) were isolated from the sponge Haliclona densaspicula. On the basis of spectral data and the Mosher ester method, the complete structures were characterized as hexacyclic diamine alkaloids, which were probably derived from 3-alkylpyridine. Compounds 1 and 2 showed relatively potent inhibitory effects on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells with IC(50) values of 1.05 and 2.14 μM, respectively.
Buyng Su Hwang; Jung Soon Oh; Eun Ju Jeong; Chung J Sim; Jung-Rae Rho
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-5
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Oceanography, Kunsan National University , Jeonbuk 573-701, South Korea, Marine BioResources Bank, Hannam University , Daejeon 306-791, South Korea, and Department of Agronomy & Medicinal Plant Resources, Gyeongnam, National University of Science and Technology , JinJu 660-758, South Korea.
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