Document Detail

Dengue: the risk to developed and developing countries.
MedLine Citation:
PMID:  8146129     Owner:  NLM     Status:  MEDLINE    
Dengue viruses are members of the Flaviviridae, transmitted principally in a cycle involving humans and mosquito vectors. In the last 20 years the incidence of dengue fever epidemics has increased and hyperendemic transmission has been established over a geographically expanding area. A severe form, dengue hemorrhagic fever (DHF), is an immunopathologic disease occurring in persons who experience sequential dengue infections. The risk of sequential infections, and consequently the incidence of DHF, has risen dramatically, first in Asia and now in the Americas. At the root of the emergence of dengue as a major health problem are changes in human demography and behavior, leading to unchecked populations of and increased exposure to the principal domestic mosquito vector, Aedes aegypti. Virus-specified factors also influence the epidemiology of dengue. Speculations on future events in the epidemiology, evolution, and biological expression of dengue are presented.
T P Monath
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  91     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-05-05     Completed Date:  1994-05-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2395-400     Citation Subset:  IM    
Research and Medical Affairs, OraVax, Inc., Cambridge, MA 02139.
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MeSH Terms
Aedes / microbiology
Dengue / epidemiology*
Dengue Virus / genetics
Developing Countries*
Disease Outbreaks*
Disease Vectors
Flavivirus / classification,  genetics
Genetic Variation
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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