Document Detail

Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles.
MedLine Citation:
PMID:  14722886     Owner:  NLM     Status:  MEDLINE    
A prospective study of clinical and cytokine profiles of 107 infants with dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) was conducted. Fever, petechiae on the skin, and hepatomegaly were the most common clinical findings associated with DHF/DSS in infants. DSS occurred in 20.5% of the patients. Hemoconcentration and thrombocytopenia were observed in 91.5% and 92.5% of the patients, respectively. Serologic testing revealed that almost all of the patients (95.3%) had primary dengue virus infections. These data demonstrate that clinical and laboratory findings of DHF/DSS in infants are compatible with the World Health Organization's clinical diagnostic criteria for pediatric DHF. The present study is the first to report evidence of production of cytokines in infants with DHF/DSS and to describe the difference between the cytokine profile of infants with primary dengue virus infections and children with secondary infections. Overproduction of both proinflammatory cytokines (interferon-gamma and tumor necrosis factor-alpha) and anti-inflammatory cytokines (interleukin-10 and -6) may play a role in the pathogenesis of DHF/DSS in infants.
Thanh Hung Nguyen; Huan-Yao Lei; Trong Lan Nguyen; Yee-Shin Lin; Kao-Jean Huang; Bich Lien Le; Chiou-Feng Lin; Trai-Ming Yeh; Quang Ha Do; Thi Que Huong Vu; Lien-Cheng Chen; Jyh-Hsiung Huang; Thi My Lam; Ching-Chuan Liu; Scott B Halstead
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-01-09
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  189     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-14     Completed Date:  2004-02-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  221-32     Citation Subset:  AIM; IM    
Department of Dengue Hemorrhagic Fever, Children's Hospital No. 1-Ho Chi Minh City, Vietnam.
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MeSH Terms
Antibodies, Viral / blood
Blood Coagulation
Cytokines / blood*
Dengue Hemorrhagic Fever / blood,  immunology*,  physiopathology
Infant, Newborn
Interleukin-10 / blood
Liver / physiopathology
Protein C / analysis
Protein S / analysis
Tumor Necrosis Factor-alpha / analysis
Reg. No./Substance:
0/Antibodies, Viral; 0/Cytokines; 0/Protein C; 0/Protein S; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 82115-62-6/Interferon-gamma

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