| Dendroflorin retards the senescence of MRC-5 cells. | |
| | |
MedLine Citation:
|
PMID: 18468396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The influence of dendroflorin, a potentially active compound extracted from Dendrobium nobile, on cell growth and cell cycles was assessed in a human embryo lung fibroblastic MRC-5 cell line. An MTT assay indicated that dendroflorin benefits cell proliferation. Additionally, we used flow cytometry to examine the cell cycles in senescent MRC-5 cells after treatment with dendroflorin, discovering that dendroflorin could trigger cells in the G1 phase to enter the S phase. Further examination of intracellular ROS contents using DCFH-DA suggested that dendroflorin helps ROS degradation, partly elucidating the mechanism of its effects. All of the above results suggest that dendroflorin is a potential candidate with anti-senescence activity. |
| | |
Authors:
|
Jinghua Jin; Yu Liang; Hong Xie; Xue Zhang; Xinsheng Yao; Zhao Wang |
Related Documents
:
|
8810036 - Review: to bud until death: the genetics of ageing in the yeast, saccharomyces. 7507226 - Human papillomavirus 18-immortalized endocervical cells with in vitro cytokeratin expre... 20844316 - Adult-onset, short-term dietary restriction reduces cell senescence in mice. 8735906 - In vitro senescence enhances il-6 production in human gingival fibroblasts induced by l... 9356336 - Characterization of cucumber mosaic virus. iv. movement protein and coat protein are bo... 20164196 - Dynamic regulation of cd45 lateral mobility by the spectrin-ankyrin cytoskeleton of t c... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Die Pharmazie Volume: 63 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2008 Apr |
Date Detail:
|
Created Date: 2008-05-12 Completed Date: 2008-06-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
|
Languages: eng Pagination: 321-3 Citation Subset: IM |
Affiliation:
|
Protein Science Key Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, School of Medicine, Tsinghua University, Beijing, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Aging
/
drug effects* Cell Cycle / drug effects Cell Line Dendrobium / chemistry Flow Cytometry Free Radical Scavengers / pharmacology* G1 Phase / drug effects Humans Oxidative Stress / drug effects Reactive Oxygen Species / metabolism S Phase / drug effects Tetrazolium Salts Thiazoles |
| Chemical | |
Reg. No./Substance:
|
0/Free Radical Scavengers; 0/Reactive Oxygen Species; 0/Tetrazolium Salts; 0/Thiazoles; 298-93-1/thiazolyl blue |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vitro and in vivo investigations on the binary meloxicam-mannitol system.
Next Document: A new diketopiperazine alkaloid isolated from an algicolous Aspergillus flavus strain.