Document Detail

Dendritic saccharide surfactant polymers as antifouling interface materials to reduce platelet adhesion.
MedLine Citation:
PMID:  16602718     Owner:  NLM     Status:  MEDLINE    
Here, we report on the synthesis of dendritic saccharide surfactant polymers as antifouling interface materials to reduce platelet adhesion. An acetal-protected poly(amidoamine) (PAMAM) dendron (5, G = 2) was first synthesized by using aminoacetaldehyde dimethyl acetal (1) as the starting material to provide a monovalent focal structure with dimethyl acetal-protected aldehyde functionality. Maltose dendron (M4, 6) was obtained by reacting the peripheral amine groups of acetal-dendron (5) with maltonolactone. The dendritic surfactant polymers (9) were then synthesized via a two-step method by sequential addition of maltose dendron and hexanal to react with the amine groups on the poly(vinylamine) (PVAm) backbone. Surface activity of the amphiphilic glycopolymers at the air/water interface was demonstrated by reduction in water surface tension. Adsorption of the amphiphilic glycopolymers at the solid/water interface was examined on octadecyltrichlorosilane (OTS)-coated coverslips by water contact angle measurements. A nanoscale understanding of surface-induced self-assembly of the dendritic surfactant polymer on highly oriented pyrolytic graphite (HOPG) was gained using AFM operated in fluid tapping mode. A lateral ordering of adsorbing surfactant polymer was visualized with a pattern in strands 60 degrees out of alignment. The static platelet adhesion tests show that the hexyl side chains can facilitate adsorption of the surfactant polymers onto hydrophobic substrates, while the maltose dendron side chains can provide a dense canopy of protective glycocalyx-like layer as an antifouling interface to reduce platelet adhesion.
Junmin Zhu; Roger E Marchant
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Biomacromolecules     Volume:  7     ISSN:  1525-7797     ISO Abbreviation:  Biomacromolecules     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-10     Completed Date:  2006-07-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1036-41     Citation Subset:  IM    
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.
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MeSH Terms
Dendrimers / chemical synthesis,  chemistry,  pharmacology*
Molecular Structure
Oligosaccharides / chemical synthesis,  chemistry,  pharmacology*
Platelet Adhesiveness / drug effects*
Polymers / chemical synthesis,  chemistry,  pharmacology*
Reference Values
Surface Properties
Surface-Active Agents / chemical synthesis,  chemistry,  pharmacology*
Grant Support
Reg. No./Substance:
0/Dendrimers; 0/Oligosaccharides; 0/Polymers; 0/Surface-Active Agents

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