| Dendritic computation of direction selectivity and gain control in visual interneurons. | |
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MedLine Citation:
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PMID: 9236213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The extraction of motion information from time varying retinal images is a fundamental task of visual systems. Accordingly, neurons that selectively respond to visual motion are found in almost all species investigated so far. Despite its general importance, the cellular mechanisms underlying direction selectivity are not yet understood in most systems. Blocking inhibitory input to fly visual interneurons by picrotoxinin (PTX), we demonstrate that their direction selectivity arises largely from interactions between postsynaptic signals elicited by excitatory and inhibitory input elements, which are themselves only weakly tuned to opposite directions of motion. Their joint activation by preferred as well as null direction motion leads to a mixed reversal potential at which the postsynaptic response settles for large field stimuli. Assuming the activation ratio of these opponent inputs to be a function of pattern velocity can explain how the postsynaptic membrane potential saturates with increasing pattern size at different levels for different pattern velocities ("gain control"). Accordingly, we find that after blocking the inhibitory input by PTX, gain control is abolished. |
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Authors:
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S Single; J Haag; A Borst |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 17 ISSN: 0270-6474 ISO Abbreviation: J. Neurosci. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-08-28 Completed Date: 1997-08-28 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 6023-30 Citation Subset: IM; S |
Affiliation:
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Friedrich-Miescher-Laboratory, Max-Planck-Society, D-72076 Tuebingen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Computer Simulation* Dendrites / physiology Diptera / physiology* Female Interneurons / physiology*, ultrastructure Membrane Potentials / physiology Models, Neurological* Motion Perception / physiology* Neurons, Afferent / physiology Synaptic Transmission / physiology |
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