| Dendritic cells, regulatory T cells and the pathogenesis of chronic hepatitis C. | |
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MedLine Citation:
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PMID: 23076334 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hepatitis C virus (HCV) is a small, enveloped RNA virus and a major cause of chronic liver disease. Resolution of primary HCV infections depends upon the vigorous responses of CD4 (+) and CD8 (+) T cells to multiple viral epitopes. Although such broad-based responses are readily detected early during the course of infection regardless of clinical outcome, they are not maintained in individuals who develop chronic disease. Ostensibly, a variety of factors contribute to the diminished T cell responses observed in chronic, HCV-infected patients including impaired dendritic cell function and the induction of CD4 (+) FoxP3 (+) regulatory T cells. Overwhelming evidence suggests that the complex interaction of dendritic cells and regulatory T cells plays a critical role in the pathogenesis of chronic hepatitis C. |
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Authors:
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Phyllis T Losikoff; Ayssa A Self; Stephen H Gregory |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-17 |
Journal Detail:
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Title: Virulence Volume: 3 ISSN: 2150-5608 ISO Abbreviation: Virulence Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101531386 Medline TA: Virulence Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine; Rhode Island Hospital and the Warren Alpert Medical School at Brown University; Providence, RI USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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