Document Detail


Dendritic cells, regulatory T cells and the pathogenesis of chronic hepatitis C.
MedLine Citation:
PMID:  23076334     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hepatitis C virus (HCV) is a small, enveloped RNA virus and a major cause of chronic liver disease. Resolution of primary HCV infections depends upon the vigorous responses of CD4 (+) and CD8 (+) T cells to multiple viral epitopes. Although such broad-based responses are readily detected early during the course of infection regardless of clinical outcome, they are not maintained in individuals who develop chronic disease. Ostensibly, a variety of factors contribute to the diminished T cell responses observed in chronic, HCV-infected patients including impaired dendritic cell function and the induction of CD4 (+) FoxP3 (+) regulatory T cells. Overwhelming evidence suggests that the complex interaction of dendritic cells and regulatory T cells plays a critical role in the pathogenesis of chronic hepatitis C.
Authors:
Phyllis T Losikoff; Ayssa A Self; Stephen H Gregory
Related Documents :
23993984 - Hepatitis c virus (hcv) infection of peripheral blood mononuclear cells in patients wit...
23555014 - Complementary role of hcv and hiv in t-cell activation and exhaustion in hiv/hcv coinfe...
24210114 - Dynamic changes in viral population structure and compartmentalization during chronic h...
24063434 - Identification of myxobacteria-derived hiv inhibitors by a high-throughput two-step inf...
17646074 - Separation of advanced from mild fibrosis in diffuse liver disease using 31p magnetic r...
23437024 - The management of needlestick injuries.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-17
Journal Detail:
Title:  Virulence     Volume:  3     ISSN:  2150-5608     ISO Abbreviation:  Virulence     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101531386     Medline TA:  Virulence     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medicine; Rhode Island Hospital and the Warren Alpert Medical School at Brown University; Providence, RI USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dendritic cells and influenza A virus infection.
Next Document:  Identification of treatment strategies for Mycoplasma genitalium-related urethritis in male patients...