Document Detail

Dendritic cells, regulatory T cells and the pathogenesis of chronic hepatitis C.
MedLine Citation:
PMID:  23076334     Owner:  NLM     Status:  Publisher    
Hepatitis C virus (HCV) is a small, enveloped RNA virus and a major cause of chronic liver disease. Resolution of primary HCV infections depends upon the vigorous responses of CD4 (+) and CD8 (+) T cells to multiple viral epitopes. Although such broad-based responses are readily detected early during the course of infection regardless of clinical outcome, they are not maintained in individuals who develop chronic disease. Ostensibly, a variety of factors contribute to the diminished T cell responses observed in chronic, HCV-infected patients including impaired dendritic cell function and the induction of CD4 (+) FoxP3 (+) regulatory T cells. Overwhelming evidence suggests that the complex interaction of dendritic cells and regulatory T cells plays a critical role in the pathogenesis of chronic hepatitis C.
Phyllis T Losikoff; Ayssa A Self; Stephen H Gregory
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-17
Journal Detail:
Title:  Virulence     Volume:  3     ISSN:  2150-5608     ISO Abbreviation:  Virulence     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101531386     Medline TA:  Virulence     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Medicine; Rhode Island Hospital and the Warren Alpert Medical School at Brown University; Providence, RI USA.
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