| Dendritic cells produce inflammatory cytokines in response to bacterial products from Staphylococcus aureus-infected atopic dermatitis lesions. | |
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MedLine Citation:
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PMID: 21109237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atopic Dermatitis (AD) patients often acquire secondary skin infections resulting in increased inflammation. The increased inflammation occurs through the activation of multiple cell types including dendritic cells (DC). In this study, we investigated the activity of soluble products present in infected AD lesions by measuring the ability of patients' wash fluids from a quantitative culture of lesions to activate DC. We found that wash fluid derived from AD lesions induced cytokine production by murine bone marrow-derived DC, including IL-1β, IL-6, ΙL-10, and tumor necrosis factor-α. The lipoprotein lipoteichoic acid (LTA) from Staphylococcusaureus was implicated as a potent stimulus in the wash fluids as only wash fluid samples that contained LTA exerted this activity, and exogenous LTA triggered similar DC cytokine activation. Wash fluid- and LTA-stimulated DC cytokine production required MyD88, but not the platelet-activating factor receptor (PAF-R), despite the ability of LTA to function through this receptor in keratinocytes. Thus, our results support a role for DC in the worsening of AD inflammation due to secondary bacteria infections. |
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Authors:
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Timothy Voorhees; Jihoon Chang; Yongxue Yao; Mark H Kaplan; Cheong-Hee Chang; Jeffrey B Travers |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-10-30 |
Journal Detail:
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Title: Cellular immunology Volume: 267 ISSN: 1090-2163 ISO Abbreviation: Cell. Immunol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-14 Completed Date: 2011-02-07 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 1246405 Medline TA: Cell Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 17-22 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Microbiology and Immunology, the University of Michigan Medical School, Ann Arbor, MI 48109, United States. jtravers@iupui.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytokines / biosynthesis, immunology* Dendritic Cells / immunology* Dermatitis, Atopic / etiology, immunology* Humans Mice Mice, Inbred C57BL Staphylococcal Infections / complications, immunology* Staphylococcus aureus / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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HL62996/HL/NHLBI NIH HHS; R01 HL062996-12/HL/NHLBI NIH HHS; U19 AI070448/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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