| Dendritic cells in acute promyelocytic leukaemia. | |
| | |
MedLine Citation:
|
PMID: 11564070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dendritic cell (DC) differentiation was investigated in samples from two acute promyelocytic leukaemia (APL) patients with classic translocation t(15;17)(q22;q21). After 18 d of culture in the presence of granulocyte-macrophage colony-stimulating factor, interleukin 4 and tumour necrosis factor alpha, 10-15% of pathological promyelocytes had differentiated into DC-like cells, as demonstrated by immunological and functional characteristics and by analysis of CD1a+ cells. In one patient, analysed at relapse and after developing a picture of secondary myelodysplastic syndrome (MDS), three different populations of DCs were demonstrated, two of which derived from pathological myeloid precursors (the APL and the MDS clones). This patient's DCs also presented abnormal dextran uptake. Our results demonstrated that pathological myeloid precursors in APL can differentiate into DC-like elements and that different populations of pathological DCs may coexist in the same patient. |
| | |
Authors:
|
G M Rigolin; M Della Porta; R Bigoni; A Tieghi; A Cuneo; G Castoldi |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: British journal of haematology Volume: 114 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2001 Sep |
Date Detail:
|
Created Date: 2001-09-20 Completed Date: 2001-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
|
Languages: eng Pagination: 830-3 Citation Subset: IM |
Affiliation:
|
Section of Haematology, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca, 203, 44100 Ferrara, Italy. sse@dne.unife.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antigens, CD1
/
analysis Cell Differentiation Cells, Cultured Chromosomes, Human, Pair 15 Chromosomes, Human, Pair 17 Dendritic Cells / immunology*, metabolism Dextrans / metabolism Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology Humans Immunophenotyping In Situ Hybridization, Fluorescence Interleukin-4 / pharmacology Leukemia, Promyelocytic, Acute / genetics, immunology*, metabolism Myelodysplastic Syndromes / immunology Translocation, Genetic Tumor Necrosis Factor-alpha / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD1; 0/Tumor Necrosis Factor-alpha; 207137-56-2/Interleukin-4; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Results of autologous stem cell transplant in multiple myeloma patients with renal failure.
Next Document: Unrelated cord blood transplantation for adult patients with myelodysplastic syndrome-related second...