Document Detail


Dendritic cells in acute kidney injury: cues from the microenvironment.
MedLine Citation:
PMID:  23303968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dendritic cells (DCs) and macrophages are critical early initiators of innate immunity in the kidney; they also orchestrate inflammation subsequent to ischemia-reperfusion injury. Hence, these cells hold great promise as targets for pharmacological interventions. Macrophages and DCs are the most abundant leukocytes present in the kidney, and they represent a heterogeneous population of cells that are capable of inducing sterile inflammation after reperfusion, directly through the production of proinflammatory cytokines, chemokines, and other soluble inflammatory mediators, or indirectly through activation of effector T lymphocytes and natural killer T cells. In addition, recent studies have indicated that macrophages participate in tissue repair and DCs possess tolerogenic functions in normal and disease states. Understanding the function of DCs and macrophages as well as the microenvironment that governs their phenotype will shed light on the pathogenesis of kidney disease and offer novel drug targets.
Authors:
Mark D Okusa; Li Li
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transactions of the American Clinical and Climatological Association     Volume:  123     ISSN:  0065-7778     ISO Abbreviation:  Trans. Am. Clin. Climatol. Assoc.     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-10     Completed Date:  2013-07-01     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7507559     Medline TA:  Trans Am Clin Climatol Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  54-62; discussion 62-3     Citation Subset:  IM    
Affiliation:
University of Virginia Health System, Charlottesville, VA 22908, USA. mdo7y@virginia.edu
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MeSH Terms
Descriptor/Qualifier:
Acute Kidney Injury / pathology*,  physiopathology
Animals
Cellular Microenvironment / physiology*
Dendritic Cells / pathology*
Disease Models, Animal
Kidney / pathology*
Killer Cells, Natural / pathology
Macrophages / pathology
Mice
Phenotype
Receptors, Purinergic P1 / physiology
Reperfusion Injury / pathology*,  physiopathology
T-Lymphocytes / pathology
Grant Support
ID/Acronym/Agency:
5 R01 DK062324/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Purinergic P1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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