Document Detail


Dendritic cell subsets and type I interferon system in Behçet's disease: does functional abnormality in plasmacytoid dendritic cells contribute to Th1 polarization?
MedLine Citation:
PMID:  17949549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Several lines of evidence point to a polarized T-helper-1 (Th1) immune response in Behçet's disease (BD). However, it is not yet clear which factors are involved in the proposed Th1 mediated pathogenesis of BD. Dendritic cells (DCs) are antigen presenting cells which play a crucial role in the polarization of immune response. No previous study has examined the possible role of DCs in the pathogenesis of BD. We conducted both quantitative and functional analysis of the peripheral blood DC subsets in BD patients with different clinical presentations. METHODS: Thirty-eight patients with BD, 12 healthy controls (HC), and 12 patients with undifferentiated spondylarthritis (uSpA) were enrolled in the study. Peripheral blood DC subsets were analysed by flow cytometry and were further characterized for maturation with CCR7. Serum levels of interferon (IFN)-alpha and IFN-b were measured by ELISA. RESULTS: BD patients had a decreased percentage of plasmacytoid DCs (pDCs) compared to HC (p = 0.036). IFN-alpha levels were found to be increased in BD patients as compared to HC and uSPA (p < 0.001, p = 0.005, respectively). BD patients had decreased levels of IFN-Beta as compared to HC and uSpA (p = 0.013, p = 0.004, respectively). No difference was found between HC and patients with uSpA regarding IFN-Beta levels. Subgroup analysis of BD patients disclosed normalization of percentage of pDCs and the level of IFN-Beta in patients receiving IFN-alpha-2b. CONCLUSION: We suggest abnormalities in pDCs and type I IFNs appear to be a master switch leading to the pathogenicity in BD by directing immune response towards Th1.
Authors:
S Pay; I Simsek; H Erdem; A Pekel; U Musabak; A Sengul; A Dinc
Related Documents :
12067279 - Correlation between the uptake of tc-99m-sestamibi and prognostic factors in patients w...
21214039 - Alterations of erythrocyte superoxide dismutase activity in patients suffering from ast...
16282749 - Activation markers in behçet's disease.
11667989 - Nasopharyngeal endoscopy adds to reliability of clinical diagnosis of infectious mononu...
11872409 - Changes of comedonal cytokines and sebum secretion after uv irradiation in acne patients.
16350379 - Evidence of systemic cytokine release in patients undergoing cardiopulmonary bypass.
18197919 - Representative drug susceptibility patterns for guiding design of re-treatment regimens...
25395199 - Low tidal volume ventilation in patients without acute lung injury.
10774609 - The use of hyperventilation in the treatment of plateau waves in two patients with seve...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  25     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2007 Jul-Aug
Date Detail:
Created Date:  2007-10-22     Completed Date:  2008-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S34-40     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, Gulhane Military School of Medicine, Ankara, Turkey. salihp@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Behcet Syndrome / blood,  immunology*,  physiopathology
Case-Control Studies
Cell Communication
Dendritic Cells / classification*,  immunology*,  pathology
Female
Humans
Interferon-alpha / immunology
Interferon-beta / immunology
Male
Spondylarthritis / blood,  immunology
Th1 Cells / immunology*,  pathology
Chemical
Reg. No./Substance:
0/Interferon-alpha; 77238-31-4/Interferon-beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The role of infectious agents in the pathogenesis, clinical manifestations and treatment strategies ...
Next Document:  Serum galectin-3 and galectin-3 binding protein levels in Behçet's disease and their association wi...