| Dendritic cell microvilli: a novel membrane structure associated with the multifocal synapse and T-cell clustering. | |
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MedLine Citation:
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PMID: 18805966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polarizing effects of productive dendritic cell (DC)-T-cell interactions on DC cytoskeleton have been known in some detail, but the effects on DC membrane have been studied to a lesser extent. We found that T-cell incubation led to DC elongation and segregation of characteristic DC veils to the broader pole of the cell. On the opposite DC pole, we observed a novel membrane feature in the form of bundled microvilli. Each villus was approximately 100 nm in diameter and 600 to 1200 nm long. Microvilli exhibited high density of antigen-presenting molecules and costimulatory molecules and provided the physical basis for the multifocal immune synapse we observed during human DC and T-cell interactions. T cells preferentially bound to this site in clusters often contained both CD4(+) and CD8(+) T cells. |
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Authors:
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Phyllis J Fisher; Peggy A Bulur; Stanimir Vuk-Pavlovic; Franklyn G Prendergast; Allan B Dietz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-19 |
Journal Detail:
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Title: Blood Volume: 112 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-09 Completed Date: 2009-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 5037-45 Citation Subset: AIM; IM |
Affiliation:
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Mayo Clinic, Rochester, MN, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cell Adhesion / immunology Cell Communication / immunology Cell Membrane / ultrastructure Dendritic Cells / immunology, ultrastructure* Humans Immunological Synapses* / ultrastructure Microvilli / immunology* T-Lymphocytes / cytology*, immunology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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