Document Detail


Dendritic cell microvilli: a novel membrane structure associated with the multifocal synapse and T-cell clustering.
MedLine Citation:
PMID:  18805966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polarizing effects of productive dendritic cell (DC)-T-cell interactions on DC cytoskeleton have been known in some detail, but the effects on DC membrane have been studied to a lesser extent. We found that T-cell incubation led to DC elongation and segregation of characteristic DC veils to the broader pole of the cell. On the opposite DC pole, we observed a novel membrane feature in the form of bundled microvilli. Each villus was approximately 100 nm in diameter and 600 to 1200 nm long. Microvilli exhibited high density of antigen-presenting molecules and costimulatory molecules and provided the physical basis for the multifocal immune synapse we observed during human DC and T-cell interactions. T cells preferentially bound to this site in clusters often contained both CD4(+) and CD8(+) T cells.
Authors:
Phyllis J Fisher; Peggy A Bulur; Stanimir Vuk-Pavlovic; Franklyn G Prendergast; Allan B Dietz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-19
Journal Detail:
Title:  Blood     Volume:  112     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-09     Completed Date:  2009-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5037-45     Citation Subset:  AIM; IM    
Affiliation:
Mayo Clinic, Rochester, MN, USA.
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MeSH Terms
Descriptor/Qualifier:
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Adhesion / immunology
Cell Communication / immunology
Cell Membrane / ultrastructure
Dendritic Cells / immunology,  ultrastructure*
Humans
Immunological Synapses* / ultrastructure
Microvilli / immunology*
T-Lymphocytes / cytology*,  immunology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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