Document Detail


Dendritic arborization in the human fetus and infant with the trisomy 18 syndrome.
MedLine Citation:
PMID:  2397592     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dendritic arborization patterns of visual cortical neurons in four cases of trisomy 18 syndrome were compared with those in 8 neurologically asymptomatic age-matched controls. The trisomy cases included a 20-week-old fetus, a term infant, a 3-month-old infant, and 6-month-old infant. Quantitative Golgi analysis showed a decrease in the mean total dendritic length of apical dendrites in layer 5 pyramidal neurons in the term infant with trisomy 18. In layer 3, an attenuated dendritic tree was observed in the earlier age groups with increased dendritic extent at 6 months. Although not conclusive, due to the small number of subjects, this preliminary study showed definitive dendritic abnormalities in the trisomy 18 syndrome.
Authors:
V Jay; F W Chan; L E Becker
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  54     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-10-12     Completed Date:  1990-10-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  291-4     Citation Subset:  IM    
Affiliation:
Division of Neuropathology (Department of Pathology), Hospital for Sick Children, Toronto, Ont., Canada.
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MeSH Terms
Descriptor/Qualifier:
Chromosomes, Human, Pair 18*
Dendrites / ultrastructure*
Fetus / anatomy & histology*
Humans
Syndrome
Trisomy*
Visual Cortex / embryology,  ultrastructure*

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