Document Detail


Dendritic spine alterations in neocortical pyramidal neurons following postnatal neuronal Nogo-A knockdown.
MedLine Citation:
PMID:  20938157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The myelin-associated protein Nogo-A is a well-known inhibitor of axonal regeneration and compensatory plasticity, yet functions of neuronal Nogo-A are not as clear. The present study examined the effects of decreased levels of neuronal Nogo-A on dendritic spines of developing neocortical neurons. Decreased Nogo-A levels in these neurons resulted in lowered spine density and an increase in filopodial type protrusions. These results suggest a role for neuronal Nogo-A in maintaining a spine phenotype in neocortical pyramidal cells.
Authors:
A D Pradhan; A M Case; R G Farrer; S Y Tsai; J L Cheatwood; J L Martin; G L Kartje
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-10-13
Journal Detail:
Title:  Developmental neuroscience     Volume:  32     ISSN:  1421-9859     ISO Abbreviation:  Dev. Neurosci.     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-16     Completed Date:  2011-03-21     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  7809375     Medline TA:  Dev Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  313-20     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Affiliation:
Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, Ill., USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Western
Cell Line
Dendritic Spines / metabolism,  ultrastructure*
Gene Knockdown Techniques
Humans
Image Processing, Computer-Assisted
Male
Microscopy, Confocal
Myelin Proteins / genetics,  metabolism*
Neocortex / metabolism,  pathology*
Pyramidal Cells / metabolism,  ultrastructure*
RNA Interference
Rats
Grant Support
ID/Acronym/Agency:
I01 RX000828/RX/RRD VA; R01 NS040960/NS/NINDS NIH HHS; R56 NS040960/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Myelin Proteins; 0/Nogo protein
Comments/Corrections

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