| Dendritic cell responses to surface properties of clinical titanium surfaces. | |
| | |
MedLine Citation:
|
PMID: 20977948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dendritic cells (DCs) play pivotal roles in responding to foreign entities during the innate immune response and in initiating effective adaptive immunity as well as maintaining immune tolerance. The sensitivity of DCs to foreign stimuli also makes them useful cells to assess the inflammatory response to biomaterials. Elucidating material property-DC phenotype relationships using a well-defined biomaterial system is expected to provide criteria for immunomodulatory biomaterial design. Clinical titanium (Ti) substrates, including pretreatment (PT), sand blasted and acid etched (SLA), and modified SLA (modSLA), with different roughnesses and surface energies were used to treat DCs and resulted in differential DC responses. PT and SLA induced a mature DC (mDC) phenotype, while modSLA promoted a non-inflammatory environment by supporting an immature DC (iDC) phenotype, based on surface marker expression, cytokine production profiles and cell morphology. Principal component analysis (PCA) confirmed these experimental results, and also indicated that the non-stimulating property of modSLA covaried with certain surface properties, such as high surface hydrophilicity, percent oxygen and percent Ti of the substrates. In addition to previous research that demonstrated superior osteogenic properties of modSLA compared with PT and SLA, the results reported herein indicates that modSLA may further benefit implant osteointegration by reducing local inflammation and its associated osteoclastogenesis. |
| | |
Authors:
|
Peng Meng Kou; Zvi Schwartz; Barbara D Boyan; Julia E Babensee |
Related Documents
:
|
18182458 - Plasticity of dendritic cell function in response to prostaglandin e2 (pge2) and interf... 11801668 - Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquire... 11854838 - Misoprostol modulation of dendritic cell function in immune responses. 20116418 - Dc-chol/dope cationic liposomes: a comparative study of the influence factors on plasmi... 21880338 - Beta-d-(1→4)-galactan-containing side chains in rg-i regions of pectic polysaccharide... 19647058 - Involvement of no in the inhibitory effect of calotropis procera latex protein fraction... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-25 |
Journal Detail:
|
Title: Acta biomaterialia Volume: 7 ISSN: 1878-7568 ISO Abbreviation: Acta Biomater Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-01-31 Completed Date: 2011-05-19 Revised Date: 2012-03-07 |
Medline Journal Info:
|
Nlm Unique ID: 101233144 Medline TA: Acta Biomater Country: England |
Other Details:
|
Languages: eng Pagination: 1354-63 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
|
Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Differentiation Cytokines / metabolism Dendritic Cells / immunology* Humans Microscopy, Electron, Scanning Osteoblasts / cytology, metabolism, ultrastructure Principal Component Analysis Surface Properties Titanium / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
|
AR052102/AR/NIAMS NIH HHS; EB004633/EB/NIBIB NIH HHS; R01 AR052102-04/AR/NIAMS NIH HHS; R01 EB004633-04/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cytokines; 7440-32-6/Titanium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Three-dimensional laser micro- and nano-structuring of acrylated poly(ethylene glycol) materials and...
Next Document: Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascul...