Document Detail

Dendritic Cell Generation from Highly Purified CD14+Monocytes.
MedLine Citation:
PMID:  21374268     Owner:  NLM     Status:  In-Data-Review    
Dendritic cells (DC) play a pivotal role in the function of the immune system, for they are the primary antigen-presenting cells (APC) in the activation of naive T-lymphocyte responses (1). Recent studies have uncovered complexity in the DC lineage with several subsets, functions, and maturational stages. Although it is generally accepted that human DC derive from hematopoietic progenitor cells (2-9), it is not clear at present whether DC cells and their precursors represent a separate hematopoietic lineage or whether DC should be seen as specialized macrophages with particular morphological, molecular, and functional features. Several lines of evidence point to DC and monocytes/ macrophages being offspring of the same CD34(+) hematopoietic progenitor cell (3-5,12-14, and reviewed in ([10,11].) DC committed precursor cells have also been identified in peripheral blood (15-18).
W F Pickl; O Majdic; W Knapp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular medicine     Volume:  64     ISSN:  1543-1894     ISO Abbreviation:  Methods Mol. Med.     Publication Date:  2001  
Date Detail:
Created Date:  2011-03-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101123138     Medline TA:  Methods Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-96     Citation Subset:  -    
Institute of Immunology, University of Vienna Medical School, Vienna, Austria.
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