Document Detail


Dendritic Cell Generation from Highly Purified CD14+Monocytes.
MedLine Citation:
PMID:  21374268     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Dendritic cells (DC) play a pivotal role in the function of the immune system, for they are the primary antigen-presenting cells (APC) in the activation of naive T-lymphocyte responses (1). Recent studies have uncovered complexity in the DC lineage with several subsets, functions, and maturational stages. Although it is generally accepted that human DC derive from hematopoietic progenitor cells (2-9), it is not clear at present whether DC cells and their precursors represent a separate hematopoietic lineage or whether DC should be seen as specialized macrophages with particular morphological, molecular, and functional features. Several lines of evidence point to DC and monocytes/ macrophages being offspring of the same CD34(+) hematopoietic progenitor cell (3-5,12-14, and reviewed in ([10,11].) DC committed precursor cells have also been identified in peripheral blood (15-18).
Authors:
W F Pickl; O Majdic; W Knapp
Related Documents :
10971388 - Determination of helper t-cell precursor frequencies against non-haemopoietic cells: co...
7911708 - Functional analysis of human bronchial mucosal t cells extracted with interleukin-2.
9731068 - Treatment of b-cell lymphoma with chimeric igg and single-chain fv antibody-interleukin...
3489528 - Secretion of glycosylated human interleukin-2 by recombinant mammalian cell lines.
25158258 - Effects of rifampicin on osteogenic differentiation and proliferation of human mesenchy...
7528088 - Particular phenotypic profile of blood lymphocytes during obliterative bronchiolitis sy...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular medicine     Volume:  64     ISSN:  1543-1894     ISO Abbreviation:  Methods Mol. Med.     Publication Date:  2001  
Date Detail:
Created Date:  2011-03-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101123138     Medline TA:  Methods Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-96     Citation Subset:  -    
Affiliation:
Institute of Immunology, University of Vienna Medical School, Vienna, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Generation of dendritic cells from lymphoid precursors.
Next Document:  Generation of blood-derived human dendritic cells for antitumor immunotherapy.