| Dendritic cell dysfunction during primary HIV-1 infection. | |
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MedLine Citation:
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PMID: 21969335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dendritic cells have critical roles for generating and fine-tuning adaptive immune responses and for regulating immune activity through cytokine secretion. In this study, we analyzed functional properties of dendritic cells in primary human immunodeficiency virus type 1 (HIV-1) infection. We found substantial disarray of the functional properties of myeloid and plasmacytoid dendritic cells in acute HIV-1 infection, which included defective antigen-presenting and cytokine secretion properties and was associated with a distinct surface expression profile of immunomodulatory dendritic cell receptors from the leukocyte immunoglobulin-like receptor family. These data indicate that key functional properties of dendritic cells are compromised during primary HIV-1 infection. |
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Authors:
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Jinghe Huang; Yue Yang; Maha Al-Mozaini; Patrick S Burke; Jill Beamon; Mary F Carrington; Katherine Seiss; Jennifer Rychert; Eric S Rosenberg; Mathias Lichterfeld; Xu G Yu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-10-03 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 204 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-14 Completed Date: 2011-12-14 Revised Date: 2012-05-10 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1557-62 Citation Subset: AIM; IM |
Affiliation:
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Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigen Presentation Cross-Sectional Studies Dendritic Cells / immunology*, metabolism Female HIV Infections / immunology* HIV-1 / immunology* Humans Immunity, Cellular Interleukin-12 / metabolism Male Middle Aged Tumor Necrosis Factor-alpha / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AI074415/AI/NIAID NIH HHS; AI078799/AI/NIAID NIH HHS; R01 AI078799/AI/NIAID NIH HHS; R21 AI093203-01A1/AI/NIAID NIH HHS; R21 AI093203-02/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Tumor Necrosis Factor-alpha; 187348-17-0/Interleukin-12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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