Document Detail

Dendrimers in gene delivery.
MedLine Citation:
PMID:  16310284     Owner:  NLM     Status:  MEDLINE    
Dendrimers have unique molecular architectures and properties that make them attractive materials for the development of nanomedicines. Key properties such as defined architecture and a high ratio of multivalent surface moieties to molecular volume also make these nanoscaled materials highly interesting for the development of synthetic (non-viral) vectors for therapeutic nucleic acids. Rational development of such vectors requires the link to be made between dendrimer structure and the morphology and physicochemistry of the respective nucleic acid complexes and, furthermore, to the biological performance of these systems at the cellular and systemic level. The review focuses on the current understanding of the role of dendrimers in those aspects of synthetic vector development. Dendrimer-based transfection agents have become routine tools for many molecular and cell biologists but therapeutic delivery of nucleic acids remains a challenge.
Christine Duf?s; Ijeoma F Uchegbu; Andreas G Sch?tzlein
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Publication Detail:
Type:  Journal Article; Review     Date:  2005-11-28
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  57     ISSN:  0169-409X     ISO Abbreviation:  Adv. Drug Deliv. Rev.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-01-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2177-202     Citation Subset:  IM    
Cancer Research UK Centre for Oncology and Applied Pharmacology, Beatson Laboratories, Glasgow University, Glasgow G61 1BD, UK.
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MeSH Terms
Chemistry, Physical
Dendrimers* / chemistry
Gene Expression
Gene Therapy / methods*
Gene Transfer Techniques*
Genetic Vectors
Physicochemical Phenomena
Reg. No./Substance:

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