| Dendrimers in gene delivery. | |
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MedLine Citation:
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PMID: 16310284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dendrimers have unique molecular architectures and properties that make them attractive materials for the development of nanomedicines. Key properties such as defined architecture and a high ratio of multivalent surface moieties to molecular volume also make these nanoscaled materials highly interesting for the development of synthetic (non-viral) vectors for therapeutic nucleic acids. Rational development of such vectors requires the link to be made between dendrimer structure and the morphology and physicochemistry of the respective nucleic acid complexes and, furthermore, to the biological performance of these systems at the cellular and systemic level. The review focuses on the current understanding of the role of dendrimers in those aspects of synthetic vector development. Dendrimer-based transfection agents have become routine tools for many molecular and cell biologists but therapeutic delivery of nucleic acids remains a challenge. |
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Authors:
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Christine Duf?s; Ijeoma F Uchegbu; Andreas G Sch?tzlein |
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Publication Detail:
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Type: Journal Article; Review Date: 2005-11-28 |
Journal Detail:
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Title: Advanced drug delivery reviews Volume: 57 ISSN: 0169-409X ISO Abbreviation: Adv. Drug Deliv. Rev. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-12 Completed Date: 2006-01-31 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8710523 Medline TA: Adv Drug Deliv Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 2177-202 Citation Subset: IM |
Affiliation:
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Cancer Research UK Centre for Oncology and Applied Pharmacology, Beatson Laboratories, Glasgow University, Glasgow G61 1BD, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemistry, Physical Dendrimers* / chemistry Gene Expression Gene Therapy / methods* Gene Transfer Techniques* Genetic Vectors Humans Physicochemical Phenomena |
| Chemical | |
Reg. No./Substance:
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0/Dendrimers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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