| Dendrimer and cancer: a patent review (2006 - present). | |
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MedLine Citation:
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PMID: 23339480 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Dendrimers were widely used in cancer diagnosis and therapy during the past decade. The surface functionalities allow bioactive molecules such as imaging probes, therapeutic compounds, targeting ligands to be present on dendrimer surface in a multivalent fashion. In addition, the interior pockets as well as the charged surface of dendrimer can be encapsulated/bound with anti-cancer drugs or therapeutic DNAs/siRNAs. Areas covered: The combination of dendrimer chemistry and new cancer therapy techniques such as radiotherapy, photodynamic therapy, neuron capture therapy, and photothermal therapy provides promising strategies in future cancer therapy. Here, we focused on recent advances on this topic in the patents (2006 - present) and discussed the advantages of dendrimer technology in these inventions. Expert opinion: The challenges and perspectives of dendrimer-based theranostics for cancer diagnosis and therapy are discussed. Future efforts in this area should be focused on designing materials to solve problems such as cancer metastasis, multidrug resistance (MDR) in cancer cells, and early-stage cancer diagnosis. |
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Authors:
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Xiaopan Cai; Jingjing Hu; Jianru Xiao; Yiyun Cheng |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-23 |
Journal Detail:
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Title: Expert opinion on therapeutic patents Volume: - ISSN: 1744-7674 ISO Abbreviation: Expert Opin Ther Pat Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9516419 Medline TA: Expert Opin Ther Pat Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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East China Normal University, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences , Shanghai, 200241, P.R , China yycheng@mail.ustc.edu.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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