Document Detail


Demonstration of spirochetes in cardiac biopsies of patients with Lyme disease.
MedLine Citation:
PMID:  2732509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac involvement occurring early in Borrelia burgdorferi infection is a clinical manifestation of human Lyme disease. Therefore, two patients with acute complete atrioventricular heart blocks and unexplained recurrent dizziness were studied. Both patients had significantly elevated serum titers of IgM and IgG antibodies to B. burgdorferi. Right ventricular subendocardial biopsies showed dense infiltrates consisting of lymphocytes and plasma cells. Silver staining revealed spirochetes characteristic of B. burgdorferi near and in the infiltrates, between the muscle fibers, and in the endocardium. One patient responded to penicillin; the other did not, necessitating installation of a pacemaker. Thus, permanent heart damage may result from cardiac involvement in Lyme disease.
Authors:
J de Koning; J A Hoogkamp-Korstanje; M R van der Linde; H J Crijns
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  160     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-07-27     Completed Date:  1989-07-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  150-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Laboratory for Public Health, Leeuwarden, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Bacterial / analysis
Biopsy
Borrelia / immunology,  isolation & purification*
Dizziness / etiology
Female
Heart / microbiology*
Heart Block / etiology*
Humans
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Lyme Disease / complications*
Male
Myocardium / pathology
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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