Document Detail

Demonstration of spirochetes in cardiac biopsies of patients with Lyme disease.
MedLine Citation:
PMID:  2732509     Owner:  NLM     Status:  MEDLINE    
Cardiac involvement occurring early in Borrelia burgdorferi infection is a clinical manifestation of human Lyme disease. Therefore, two patients with acute complete atrioventricular heart blocks and unexplained recurrent dizziness were studied. Both patients had significantly elevated serum titers of IgM and IgG antibodies to B. burgdorferi. Right ventricular subendocardial biopsies showed dense infiltrates consisting of lymphocytes and plasma cells. Silver staining revealed spirochetes characteristic of B. burgdorferi near and in the infiltrates, between the muscle fibers, and in the endocardium. One patient responded to penicillin; the other did not, necessitating installation of a pacemaker. Thus, permanent heart damage may result from cardiac involvement in Lyme disease.
J de Koning; J A Hoogkamp-Korstanje; M R van der Linde; H J Crijns
Related Documents :
19632539 - Echocardiographic features of cardiac amyloidosis presenting as endomyocardial disease ...
2860699 - Cardiovascular manifestations of systemic lupus erythematosus: current perspective.
15855089 - Myocardial late enhancement in contrast-enhanced cardiac mri: distinction between infar...
11922029 - Tuberculosis myocarditis: a case report.
3241319 - Senile cardiac amyloidosis in senescence accelerated mouse (sam).
21969379 - Microrna-processing enzyme dicer is required in epicardium for coronary vasculature dev...
4035589 - Teratogenicity of dimethoxyethyl phthalate and its metabolites methoxyethanol and metho...
2203559 - Is silent ischemia a treatable risk factor in patients with angina pectoris?
22490579 - Neuregulin-1 attenuates mitochondrial dysfunction in a rat model of heart failure.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  160     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-07-27     Completed Date:  1989-07-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  150-3     Citation Subset:  AIM; IM    
Department of Pathology, Laboratory for Public Health, Leeuwarden, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antibodies, Bacterial / analysis
Borrelia / immunology,  isolation & purification*
Dizziness / etiology
Heart / microbiology*
Heart Block / etiology*
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Lyme Disease / complications*
Myocardium / pathology
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Detection of HIV-specific antibodies in infancy by isoelectric focusing and affinity immunoblotting.
Next Document:  Risk factors associated with HIV infection in Uganda.