| Demonstration of placental vascular anatomy in monochorionic twin gestations. | |
| | |
MedLine Citation:
|
PMID: 11815867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Invasive treatment modalities for severe chronic twin-to-twin transfusion syndrome (TTTS), such as fetoscopic laser coagulation of communicating vessels, have revived the need for detailed studies of placental angioarchitecture. We describe a practical placental vascular injection technique using alcohol-resistant tissue-staining dyes. Injection of color-coded gelatin-dye mixtures effectively delineated the intertwin vasculature, and allowed unequivocal macroscopic classification of vascular communications as artery-to-artery, vein-to-vein, or deep artery-to-vein anastomoses. The existence of deep artery-to-vein anastomoses was further confirmed by light microscopic demonstration of venous dye of one twin and arterial dye of the opposite twin within the same stem villus. Furthermore, the injection technique allowed determination of the caliber of the anastomoses, the direction of the artery-to-vein anastomoses, and the relative vascular territory of each twin. Documenting the vascular communications in monochorionic twin placentas with and without TTTS may enhance our understanding of the pathogenesis of chronic TTTS. Correlating the anastomotic patterns and location of the laser coagulation scars with post-ablation outcome will aid in the design of rational therapeutic methods for this often lethal condition. |
| | |
Authors:
|
Monique E De Paepe; Sarah Burke; Francois I Luks; Halit Pinar; Don B Singer |
Related Documents
:
|
21044027 - Incidence and prevention of thromboembolic events in one stage bilateral total hip arth... 7060947 - Fibrinolytic guidelines in diabetes. 12584387 - Principle mechanisms underlying venous thromboembolism: epidemiology, risk factors, pat... 8976357 - Thrombolytic and endovascular treatment of peripartum iliac vein thrombosis: a case rep... 4015367 - Sutureless intraluminal graft for repair of abdominal aortic aneurysm. 1838107 - Paf antagonists inhibit monocrotaline-induced lung injury and pulmonary hypertension. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Volume: 5 ISSN: 1093-5266 ISO Abbreviation: Pediatr. Dev. Pathol. Publication Date: 2002 Jan-Feb |
Date Detail:
|
Created Date: 2002-01-29 Completed Date: 2002-03-13 Revised Date: 2006-05-08 |
Medline Journal Info:
|
Nlm Unique ID: 9809673 Medline TA: Pediatr Dev Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 37-44 Citation Subset: IM |
Affiliation:
|
Department of Pathology, Women and Infants' Hospital, 101 Dudley Street, Providence, RI 02905, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Arteriovenous Anastomosis / pathology Chorion / blood supply Diseases in Twins Female Fetofetal Transfusion / etiology, pathology* Gestational Age Humans Infant, Newborn Placenta / blood supply* Placental Circulation / physiology* Pregnancy Twins, Dizygotic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Study of the regression process in cardiac rhabdomyomas.
Next Document: Cutaneous lymphoblastic lymphoma in children: report of six cases with precursor B-cell lineage.