Document Detail

Demonstration of myocardial necrosis in the presence of advanced putrefaction.
MedLine Citation:
PMID:  11197628     Owner:  NLM     Status:  MEDLINE    
Samples of heart tissue were investigated in two series for the detectability of myocardial necrosis after artificial and natural putrefaction, respectively. In the first series heart tissue with and without infarction was artificially subjected to humid and dry autolysis and putrefaction. In the second investigation heart tissue was obtained from exhumed bodies after periods of burial ranging between 10 and 929 days. Besides histology a variety of immunohistochemical markers were applied and C5b-9 gave positive results even after long periods of artificial and natural putrefaction. From the methods tested, this was by far the most sensitive method with a high robustness against putrefaction. NP57, which indicates neutrophilic leucocytes could be demonstrated considerably longer after humid putrefaction than after dry putrefaction. The time limits of detection were considerably longer than for H&E. These two methods are the methods of choice for the detection of myocardial infarction and leucocyte infiltration in advanced stages of putrefaction.
C Ortmann; H Pfeiffer; B Brinkmann
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of legal medicine     Volume:  114     ISSN:  0937-9827     ISO Abbreviation:  Int. J. Legal Med.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-25     Completed Date:  2001-03-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9101456     Medline TA:  Int J Legal Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  IM    
Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, 48129 Münster, Germany.
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MeSH Terms
Antibodies, Monoclonal / metabolism*
Autolysis / pathology*
Autopsy / methods*
Biological Markers
Cause of Death
Chemotaxis, Leukocyte
Complement Membrane Attack Complex / metabolism*
Middle Aged
Myocardial Infarction / pathology*
Sensitivity and Specificity
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Biological Markers; 0/Complement Membrane Attack Complex

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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