Document Detail


Demonstration of human T lymphotropic virus type I (HTLV-I)-specific T cell responses from seronegative and polymerase chain reaction-negative persons exposed to HTLV-I.
MedLine Citation:
PMID:  8035019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human T lymphotropic virus type I (HTLV-I) is a human retrovirus etiologically linked to adult T cell leukemia and the progressive chronic neurologic disease HTLV-I-associated myelopathy/tropical spastic paraparesis. Described is a method that measures the production of interleukin-2 from HTLV-I synthetic peptide-stimulated peripheral blood lymphocytes (PBL) of HTLV-I-infected persons. The peptides correspond to immunogenic regions of the HTLV-I Env and Tax proteins. Significantly, this assay demonstrated T cell responses to these HTLV-I peptides from coded PBL samples in 7 of 19 HTLV-I-seronegative polymerase chain reaction-negative persons known to have been exposed to HTLV-I but in none of 16 matched controls without risk factors for exposure (P = .007). The implications of this finding are discussed.
Authors:
M Nishimura; A G Kermode; M Clerici; G M Shearer; J A Berzofsky; T Uchiyama; S Z Wiktor; E Pate; B Maloney; A Manns
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  170     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-08-18     Completed Date:  1994-08-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  334-8     Citation Subset:  AIM; IM; X    
Affiliation:
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acid Sequence
Child, Preschool
Cohort Studies
Female
Gene Products, env / chemistry,  immunology
Gene Products, tax / chemistry,  immunology
HTLV-I Antigens / chemistry,  immunology
HTLV-I Infections / transmission*
Human T-lymphotropic virus 1 / immunology*
Humans
Infant
Interleukin-2 / biosynthesis*
Molecular Sequence Data
Polymerase Chain Reaction
T-Lymphocytes / immunology*
Chemical
Reg. No./Substance:
0/Gene Products, env; 0/Gene Products, tax; 0/HTLV-I Antigens; 0/Interleukin-2

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