Document Detail

Demonstration of calcification fronts by in vivo and in vitro tetracycline labelling.
MedLine Citation:
PMID:  6183296     Owner:  NLM     Status:  MEDLINE    
In patients with chronic renal failure estimations of the extent of calcification fronts delineated by in vivo tetracycline labelling correlated well with estimates obtained after staining the fronts with haematoxylin dye (Raina method). Similarly there was a good correlation between the Raina method and the demonstration of calcification fronts with ultraviolet (UV) light fluorescence after immersion of the bone tissue in fixative containing a freshly prepared solution of 1% tetracycline. These studies indicate that this latter is a valid and useful technique for demonstrating calcification fronts in a situation where tetracycline cannot be administered systemically.
J McClure
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  35     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1983-01-27     Completed Date:  1983-01-27     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1278-82     Citation Subset:  AIM; IM    
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MeSH Terms
Bone and Bones / pathology*
Calcinosis / pathology*
Doxycycline / diagnostic use
Eosine Yellowish-(YS)
Kidney Failure, Chronic / pathology*
Staining and Labeling
Reg. No./Substance:
17372-87-1/Eosine Yellowish-(YS); 517-28-2/Hematoxylin; 564-25-0/Doxycycline; 60-54-8/Tetracycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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