Document Detail

Demonstration of a beta-casomorphin immunoreactive material in the plasma of newborn calves after milk intake.
MedLine Citation:
PMID:  4081127     Owner:  NLM     Status:  MEDLINE    
Blood was collected from newborn calves before and after their first milk intake after birth; extracts of plasma were assayed by radioimmunoassay for the presence of beta-casomorphin-7 immunoreactive materials. No beta-casomorphin immunoreactivity was found in samples collected before milk ingestion; however, in samples collected after milk ingestion a beta-casomorphin-7 immunoreactive material was detected. Chromatographic characterization showed that this material was not identical with beta-casomorphin-7 but might rather represent a precursor thereof. The material proved resistant to enzymatic attack during a 30-min incubation period at 37 degrees C in the plasma of newborn calves, whereas beta-casomorphin-7 was degraded under these conditions. A physiological significance of beta-casomorphin-7 eventually cleaved from such a precursor material at any site in the newborn mammal is suggested.
M Umbach; H Teschemacher; K Praetorius; R Hirschhäuser; H Bostedt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Regulatory peptides     Volume:  12     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-01-28     Completed Date:  1986-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  223-30     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / blood*
Caseins / metabolism
Endorphins / blood*
Milk / metabolism*
Reg. No./Substance:
0/Caseins; 0/Endorphins; 79805-24-6/beta-casomorphins

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