Document Detail

Demonstration of antiglobulin activity in the synovial membrane of patients with rheumatoid arthritis and ankylosing spondylitis after pepsin treatment: real or artefact?
MedLine Citation:
PMID:  3098193     Owner:  NLM     Status:  MEDLINE    
The results of immunofluorescence studies in nine cases of rheumatoid arthritis and nine cases of ankylosing spondylitis are presented. Antiglobulin activity was sought with fluorescein labelled, heat aggregated human IgG and rabbit immunoglobulin (indirect immunofluorescence). A similar degree of increased staining for rheumatoid factor activity was seen after pepsin digestion in all cases of rheumatoid arthritis and three of the ankylosing spondylitic cases. This staining for rheumatoid factor could also be shown in control tissue after pepsin digestion, suggesting that the enhanced staining was an artefact.
P G Davies; P A Revell; V Mayston
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  45     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-01-02     Completed Date:  1987-01-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  821-6     Citation Subset:  IM    
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MeSH Terms
Antibodies, Anti-Idiotypic / analysis*
Arthritis, Rheumatoid / immunology*
Fluorescent Antibody Technique
Immunoglobulins / analysis
Pepsin A / pharmacology*
Plasma Cells / immunology
Rheumatoid Factor / analysis
Spondylitis, Ankylosing / immunology*
Synovial Membrane / drug effects,  immunology*
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Immunoglobulins; 9009-79-4/Rheumatoid Factor; EC A

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