Document Detail

Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase.
MedLine Citation:
PMID:  22807303     Owner:  NLM     Status:  MEDLINE    
The pathway for substrate transacylation between a fungal type I fatty acid synthase (FAS) and a nonreducing polyketide synthase (NR-PKS) was determined by in vitro reconstitution of dissected domains. System kinetics were influenced by domain dissections, and the FAS phosphopantetheinyl transferase (PPT) monodomain exhibited coenzyme A selectivity for the post-translational activation of the FAS acyl carrier protein (ACP).
Jennifer Foulke-Abel; Craig A Townsend
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-13
Journal Detail:
Title:  Chembiochem : a European journal of chemical biology     Volume:  13     ISSN:  1439-7633     ISO Abbreviation:  Chembiochem     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-29     Completed Date:  2013-01-10     Revised Date:  2013-09-05    
Medline Journal Info:
Nlm Unique ID:  100937360     Medline TA:  Chembiochem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1880-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.
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MeSH Terms
Acyl Carrier Protein / metabolism
Bacterial Proteins / chemistry,  metabolism
Coenzyme A / metabolism
Fatty Acid Synthetase Complex / chemistry,  metabolism*
Fatty Acids / metabolism
Polyketide Synthases / chemistry,  metabolism*
Protein Interaction Maps*
Protein Structure, Tertiary
Saccharomyces cerevisiae / chemistry,  enzymology*,  metabolism
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Transferases (Other Substituted Phosphate Groups) / chemistry,  metabolism
Grant Support
Reg. No./Substance:
0/Acyl Carrier Protein; 0/Bacterial Proteins; 0/Fatty Acids; 0/phosphopantetheinyl transferase; 79956-01-7/Polyketide Synthases; 85-61-0/Coenzyme A; EC 2.7.8.-/Transferases (Other Substituted Phosphate Groups); EC 6.-/Fatty Acid Synthetase Complex

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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