Document Detail

Demonstrated and inferred metabolism associated with cytosolic lipid droplets.
MedLine Citation:
PMID:  19696439     Owner:  NLM     Status:  MEDLINE    
Cytosolic lipid droplets were considered until recently to be rather inert particles of stored neutral lipid. Largely through proteomics is it now known that droplets are dynamic organelles and that they participate in several important metabolic reactions as well as trafficking and interorganellar communication. In this review, the role of droplets in metabolism in the yeast Saccharomyces cerevisiae, the fly Drosophila melanogaster, and several mammalian sources are discussed, particularly focusing on those reactions shared by these organisms. From proteomics and older work, it is clear that droplets are important for fatty acid and sterol biosynthesis, fatty acid activation, and lipolysis. However, many droplet-associated enzymes are predicted to span a membrane two or more times, which suggests either that droplet structure is more complex than the current model posits, or that there are tightly bound membranes, particularly derived from the endoplasmic reticulum, which account for the association of several of these proteins.
Joel M Goodman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-08-20
Journal Detail:
Title:  Journal of lipid research     Volume:  50     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-03-16     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2148-56     Citation Subset:  IM    
Department of Pharmacology University of Texas Southwestern Medical School Dallas TX 75390-9041, USA.
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MeSH Terms
Cytoplasmic Granules / metabolism*
Cytosol / metabolism
Drosophila melanogaster / metabolism
Fatty Acids / biosynthesis
Lipid Metabolism*
Lipids / analysis*
Saccharomyces cerevisiae / metabolism
Sterols / biosynthesis
Grant Support
Reg. No./Substance:
0/Fatty Acids; 0/Lipids; 0/Sterols

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