Document Detail

Demographics of infertility and management of unexplained infertility.
MedLine Citation:
PMID:  22951769     Owner:  NLM     Status:  Publisher    
The cause of infertility is unexplained in about 22-28% of all infertile couples. The prognosis for spontaneous pregnancy in such couples is better than in those with diagnosed causes of infertility. Traditional treatment options in this group have included expectant management, clomifene citrate, intrauterine insemination with (super ovulation plus intrauterine insemination) or without (intrauterine insemination) super ovulation and in-vitro fertilisation. Despite being more expensive, empirical clomifene and intrauterine insemination in an unstimulated cycle do not improve the chances of live birth compared with expectant management. Although unlikely to be more effective than no treatment in couples with a reasonably good prognosis, super ovulation plus intrauterine insemination has been shown to be more effective than intrauterine insemination. Any potential advantage of super ovulation plus intrauterine insemination has to be balanced against the relatively high risk of iatrogenic multiple pregnancy. In-vitro fertilisation remains the treatment of choice in longstanding unresolved infertility and, when coupled with the use of elective single embryo transfer, can minimise the risk of multiple pregnancies. Data from randomised trials confirming the superiority of in-vitro fertilisation over expectant management is limited.
Mohan S Kamath; Siladitya Bhattacharya
Related Documents :
16024539 - Recombinant versus urinary gonadotrophins for triggering ovulation in assisted conception.
11011459 - Response rates of victorian general practitioners to a mailed survey on miscarriage: ra...
24953519 - Impact of periodontal therapy on general health: evidence from insurance data for five ...
11473509 - Birth order and risk for schizophrenia: a 31-year follow-up of the northern finland 196...
8876519 - Spina bifida and cleft lip among newborns of norwegian women with epilepsy: changes rel...
9369849 - Pregnancy outcomes in women with inflammatory bowel disease--a population-based cohort ...
9773389 - Two cases of primary pulmonary hypertension diagnosed during pregnancy.
19909949 - Clinical outcomes for various causes of infertility with natural-cycle in vitro fertili...
6353839 - Insulin-induced hypoglycemia in pregnant diabetics. maternal and fetal cardiovascular r...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-27
Journal Detail:
Title:  Best practice & research. Clinical obstetrics & gynaecology     Volume:  -     ISSN:  1532-1932     ISO Abbreviation:  Best Pract Res Clin Obstet Gynaecol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101121582     Medline TA:  Best Pract Res Clin Obstet Gynaecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Reproductive Medicine Unit, Christian Medical College, Vellore, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The male victim of sexual assault.
Next Document:  [Schizophrenic Psychoses with Bipolar Course - Implications for Nosology and Treatment].