Document Detail

Demographics and changes in medical/interventional treatment of coronary artery disease patients over a 3.5-year period in Japan: the Japanese Coronary Artery Disease Study: trend examination.
MedLine Citation:
PMID:  18724012     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cardiovascular medicine has undergone rapid changes in recent years, but there are insufficient reports using large cohorts regarding these changes for Japanese coronary artery disease (CAD) patients. Hence, a large-scale prospective observational study was needed. METHODS AND RESULTS: A total of 36,298 patients were registered over 6 periods. Patients with hypertension, hyperlipidemia, obesity, and impaired glucose tolerance increased in number, while those with old myocardial infarction (MI), smoking habit, and family history of CAD decreased. Regarding the trends in interventional procedures, stent use increased in both the whole cohort and the acute MI subgroup, while the use of only medical control decreased. Regarding prescription trends, angiotensin-receptor blockers increased while nitrates decreased. CONCLUSIONS: In a period of 3.5 years, significant changes were observed for both interventional procedures and medication, which might be related to the well-timed compliance of physicians with published evidence. However, these changes were not related to changes in the event rates, at least over the short term. Although careful attention should be paid in interpreting the results, because this is an observational study and the background of patients in each cohort might have been heterogeneous, such investigations should be constantly conducted for evidence-based practice.
Takahide Kohro; Doubun Hayashi; Yoshihiro Okada; Tsutomu Yamazaki; Ryozo Nagai;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2009-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1397-402     Citation Subset:  IM    
Department of Translational Research for Healthcare and Clinical Science, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
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MeSH Terms
Asian Continental Ancestry Group
Coronary Artery Disease / complications,  epidemiology*,  therapy*
Glucose Intolerance / complications,  epidemiology,  therapy
Hyperlipidemias / complications,  epidemiology,  therapy
Hypertension / complications,  epidemiology,  therapy
Japan / epidemiology
Myocardial Infarction / complications,  epidemiology,  therapy
Obesity / complications,  epidemiology,  therapy
Population Dynamics*
Prospective Studies
Time Factors

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