Document Detail

Demographic and intrapartum characteristics of term pregnancies with early-onset neonatal seizures.
MedLine Citation:
PMID:  11324366     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the demographic and intrapartum factors of term pregnancies in which early-onset neonatal seizures developed with the characteristics of a large, unselected control population. STUDY DESIGN: Pregnancies delivered at term (gestational age > or = 37 weeks) in one birthing unit between 1984 and 1995 with a discharge diagnosis of neonatal seizures were identified. Maternal and neonatal charts of these patients were reviewed to confirm the diagnosis of early-onset seizure (EOS) which was defined as a clinical or EEG-diagnosed seizure within 72 hours of life. Demographic and intrapartum factors were compared between these EOS cases and all singleton term pregnancies delivered over the same time period in which there was no EOS. A regression model was then developed to determine factors predictive of EOS. RESULTS: Of 80,561 total deliveries during the 11-year study period, there were 64,340 control and 62 EOS (0.1%) deliveries. Regression modeling identified NICU admission, depressed 1- and 5-minute Apgar scores, and neonatal intubation as predictors of EOS, but not operative vaginal, vaginal breech, or cesarean delivery. CONCLUSION: Depressed condition at birth and/or the requirement for NICU care was the most important risk associated with early seizures in term infants.
Y Sorokin; S Blackwell; T Reinke; N Kazzi; S Berman; D Bryant
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  21     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-27     Completed Date:  2001-09-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-2     Citation Subset:  IM    
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Hutzel Hospital, Detroit Medical Center, Wayne State University, Detroit, MI, USA.
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MeSH Terms
Apgar Score
Case-Control Studies
Infant, Newborn
Intensive Care Units, Neonatal
Obstetric Labor Complications / epidemiology*
Regression Analysis
Risk Factors
Seizures / epidemiology*

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