Document Detail

Demographic, ethnic, and geographic differences between human T cell lymphotropic virus (HTLV) type I-seropositive carriers and persons with HTLV-I Gag-indeterminate Western blots in Central Africa.
MedLine Citation:
PMID:  9237719     Owner:  NLM     Status:  MEDLINE    
Using stringent Western blot (WB) criteria, human T cell lymphotropic virus (HTLV) type I seroprevalence among 3783 persons from representative rural populations of Cameroon averaged 1.1% and was higher in females (1.5%) and in Pygmies (2.0%), increasing with age. Furthermore, an HTLV-I Gag-indeterminate WB profile (HGIP), exhibiting strong reactivities to p19, p26, p28, p32, p36, and pr 53 but lacking both p24 and env reactivity, was observed in 1.6% of the same populations. The prevalence of the HGIP was similar between males and females, did not increase with age, and appeared to cluster in tropical forests of southern Cameroon, especially among Pygmies (reaching 4%). These contrasting epidemiologic features, together with the lack of detection by polymerase chain reaction of HTLV-I sequences in the peripheral blood mononuclear cells of the persons with HGIP, strongly suggest that such a WB profile does not appear to reflect an HTLV-I-related viral infection but possibly an environmental (viral or parasitic) factor endemic in tropical rain forest areas.
P Mauclère; J Y Le Hesran; R Mahieux; R Salla; J Mfoupouendoun; E T Abada; J Millan; G de Thé; A Gessain
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  176     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-08-25     Completed Date:  1997-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  505-9     Citation Subset:  AIM; IM; X    
Centre Pasteur du Cameroun, ORSTOM-OCEAC, and AIDS Control Unit, Yaoundé, Cameroon.
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MeSH Terms
Age Factors
Antibodies, Viral / blood*
Blotting, Western / methods
Cameroon / epidemiology
Carrier State*
DNA, Viral / blood
Gene Products, gag*
HTLV-I Infections / epidemiology*,  ethnology,  virology
Human T-lymphotropic virus 1 / genetics,  immunology*
Middle Aged
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Viral; 0/Gene Products, gag

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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