Document Detail


Demographic, ethnic, and geographic differences between human T cell lymphotropic virus (HTLV) type I-seropositive carriers and persons with HTLV-I Gag-indeterminate Western blots in Central Africa.
MedLine Citation:
PMID:  9237719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using stringent Western blot (WB) criteria, human T cell lymphotropic virus (HTLV) type I seroprevalence among 3783 persons from representative rural populations of Cameroon averaged 1.1% and was higher in females (1.5%) and in Pygmies (2.0%), increasing with age. Furthermore, an HTLV-I Gag-indeterminate WB profile (HGIP), exhibiting strong reactivities to p19, p26, p28, p32, p36, and pr 53 but lacking both p24 and env reactivity, was observed in 1.6% of the same populations. The prevalence of the HGIP was similar between males and females, did not increase with age, and appeared to cluster in tropical forests of southern Cameroon, especially among Pygmies (reaching 4%). These contrasting epidemiologic features, together with the lack of detection by polymerase chain reaction of HTLV-I sequences in the peripheral blood mononuclear cells of the persons with HGIP, strongly suggest that such a WB profile does not appear to reflect an HTLV-I-related viral infection but possibly an environmental (viral or parasitic) factor endemic in tropical rain forest areas.
Authors:
P Mauclère; J Y Le Hesran; R Mahieux; R Salla; J Mfoupouendoun; E T Abada; J Millan; G de Thé; A Gessain
Related Documents :
15854229 - Human t-cell leukemia virus type i (htlv-i) infection and the onset of adult t-cell leu...
202959 - Feline oncornavirus-associated cell membrane antigen: evidence for an immunologically c...
3646279 - Necessity and methods of htlv-iii inactivation in contact lens practice.
14501789 - Domestic cats infected with lion or puma lentivirus develop anti-feline immunodeficienc...
2982729 - Inhibition by human t-lymphotropic virus (htlv-i) of t-lymphocyte mitogenesis: failure ...
2280259 - Prevalence of human t-cell leukemia virus antibody among heterosexuals living in amster...
6260639 - Adoptive transfer of delayed-type hypersensitivity to sendai virus. iii. effect of h-2 ...
8394469 - The endogenous ecotropic murine retroviruses emv-16 and emv-17 are both capable of prod...
8195369 - Use of pcr-enzyme immunoassay for identification of influenza a virus matrix rna in cli...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  176     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-08-25     Completed Date:  1997-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  505-9     Citation Subset:  AIM; IM; X    
Affiliation:
Centre Pasteur du Cameroun, ORSTOM-OCEAC, and AIDS Control Unit, Yaoundé, Cameroon.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Antibodies, Viral / blood*
Blotting, Western / methods
Cameroon / epidemiology
Carrier State*
Child
DNA, Viral / blood
Female
Gene Products, gag*
HTLV-I Infections / epidemiology*,  ethnology,  virology
Human T-lymphotropic virus 1 / genetics,  immunology*
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Viral; 0/Gene Products, gag

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Outbreak of sporotrichosis among tree nursery workers.
Next Document:  Sequential versus simultaneous combination antiretroviral regimens for the treatment of human immuno...