Document Detail

Demographic inference reveals African and European admixture in the North American Drosophila melanogaster population.
MedLine Citation:
PMID:  23150605     Owner:  NLM     Status:  MEDLINE    
Drosophila melanogaster spread from sub-Saharan Africa to the rest of the world colonizing new environments. Here, we modeled the joint demography of African (Zimbabwe), European (The Netherlands), and North American (North Carolina) populations using an approximate Bayesian computation (ABC) approach. By testing different models (including scenarios with continuous migration), we found that admixture between Africa and Europe most likely generated the North American population, with an estimated proportion of African ancestry of 15%. We also revisited the demography of the ancestral population (Africa) and found-in contrast to previous work-that a bottleneck fits the history of the population of Zimbabwe better than expansion. Finally, we compared the site-frequency spectrum of the ancestral population to analytical predictions under the estimated bottleneck model.
Pablo Duchen; Daniel Zivkovic; Stephan Hutter; Wolfgang Stephan; Stefan Laurent
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-12
Journal Detail:
Title:  Genetics     Volume:  193     ISSN:  1943-2631     ISO Abbreviation:  Genetics     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-06-07     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-301     Citation Subset:  IM    
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MeSH Terms
Bayes Theorem
Computer Simulation
Crosses, Genetic*
Drosophila melanogaster / genetics*
Genetics, Population
Models, Genetic
North America
Polymorphism, Single Nucleotide

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