| Dementia with mood symptoms in a fragile X premutation carrier with the fragile X-associated tremor/ataxia syndrome: clinical intervention with donepezil and venlafaxine. | |
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MedLine Citation:
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PMID: 16720793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors present a case of a patient with dementia with mood symptoms and multiple neurological manifestations of fragile X-associated tremor/ataxia syndrome (FXTAS). Despite a gradually deteriorating neurological course, he was managed for 2 years with combination therapy of donepezil and venlafaxine, which resulted in improvement and relative stabilization of his psychiatric status. Psychiatrists are hereby alerted to the description of a novel dementia syndrome that may respond to pharmacological intervention commonly used for other dementias. |
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Authors:
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James A Bourgeois; Faraz Farzin; James A Brunberg; Flora Tassone; Paul Hagerman; Lin Zhang; David Hessl; Randi Hagerman |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of neuropsychiatry and clinical neurosciences Volume: 18 ISSN: 0895-0172 ISO Abbreviation: J Neuropsychiatry Clin Neurosci Publication Date: 2006 |
Date Detail:
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Created Date: 2006-05-24 Completed Date: 2006-09-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8911344 Medline TA: J Neuropsychiatry Clin Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 171-7 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, University of California, Davis, Medical Center, 2230 Stockton Blvd., Sacramento, 95817, USA. james.bourgeois@ucdmc.ucdavis.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antidepressive Agents, Second-Generation / therapeutic use* Ataxia / diagnosis, drug therapy*, genetics* Atrophy Brain / pathology Cyclohexanols / therapeutic use* Dementia / diagnosis, drug therapy*, genetics* Dominance, Cerebral / physiology Dose-Response Relationship, Drug Drug Therapy, Combination Fragile X Mental Retardation Protein / genetics* Fragile X Syndrome / diagnosis, drug therapy*, genetics* Heterozygote Detection* Humans Image Processing, Computer-Assisted Indans / therapeutic use* Magnetic Resonance Imaging Male Mental Status Schedule Mood Disorders / diagnosis, drug therapy*, genetics* Neurologic Examination Neuropsychological Tests Nootropic Agents / therapeutic use* Piperidines / therapeutic use* Tremor / diagnosis, drug therapy*, genetics* Trinucleotide Repeats |
| Grant Support | |
ID/Acronym/Agency:
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HD 02274/HD/NICHD NIH HHS; HD 36071/HD/NICHD NIH HHS; NS084294/NS/NINDS NIH HHS; NS435532/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Second-Generation; 0/Cyclohexanols; 0/FMR1 protein, human; 0/Indans; 0/Nootropic Agents; 0/Piperidines; 120011-70-3/donepezil; 139135-51-6/Fragile X Mental Retardation Protein; 93413-69-5/venlafaxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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