| Dementia with Lewy bodies and Alzheimer's disease. | |
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MedLine Citation:
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PMID: 11761723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate similarities and differences between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), we undertook a demographic analysis of 277 patients from the Kathleen Price Bryan Brain Bank with an antemortem diagnosis of probable AD. Patients with additional, possibly confounding clinical and pathologic diagnoses such as infarcts, hematomas, neoplasms, and other neurodegenerative disorders, were excluded from the analysis. Neuropathologically, AD alone was present in 192 subjects (69%), and DLB was found in 85 subjects (31%). All of the DLB cases had neuropathologic evidence of AD sufficient to meet CERAD criteria for a diagnosis of definite AD plus nigral Lewy bodies. Gender, apolipoprotein E (APOE) genotype, brain weight, age at death, duration of disease and Braak stage were compared between the two groups. Statistical analyses were performed using Fisher's exact test for comparisons of categorical data and Student's t-test for comparison of means for continuous outcomes. The proportion of males and females was balanced in the combined AD and DLB populations. There was a highly statistically significant increased frequency of APOE 3/4 in males with DLB (P = 0.007). We found higher brain weights in males with DLB versus males with AD (P = 0.012). AD was more frequent in females and DLB was more frequent in males (P = 0.019). Our findings with respect to age at death, duration of disease and Braak stage within diagnostic groups confirm previously reported findings. These data suggest that Lewy bodies are more common in males affected with dementia, especially those with the APOE 3/4 genotype. |
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Authors:
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C K Rosenberg; T J Cummings; A M Saunders; C Widico; L M McIntyre; C M Hulette |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Acta neuropathologica Volume: 102 ISSN: 0001-6322 ISO Abbreviation: Acta Neuropathol. Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-12-13 Completed Date: 2002-05-23 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0412041 Medline TA: Acta Neuropathol Country: Germany |
Other Details:
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Languages: eng Pagination: 621-6 Citation Subset: IM |
Affiliation:
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Bryan Alzheimer's Disease Research Center, Department of Medicine, Division of Neurology, Box 2900, Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Aged, 80 and over Alzheimer Disease / genetics, pathology* Apolipoproteins E / genetics* Brain / pathology*, physiopathology Female Genetic Testing Genotype Humans Lewy Body Disease / genetics, pathology* Male Neurons / pathology Retrospective Studies Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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P50 AG05128/AG/NIA NIH HHS; P50, NS 39764/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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