Document Detail


Dementia with Lewy bodies and Alzheimer's disease.
MedLine Citation:
PMID:  11761723     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate similarities and differences between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), we undertook a demographic analysis of 277 patients from the Kathleen Price Bryan Brain Bank with an antemortem diagnosis of probable AD. Patients with additional, possibly confounding clinical and pathologic diagnoses such as infarcts, hematomas, neoplasms, and other neurodegenerative disorders, were excluded from the analysis. Neuropathologically, AD alone was present in 192 subjects (69%), and DLB was found in 85 subjects (31%). All of the DLB cases had neuropathologic evidence of AD sufficient to meet CERAD criteria for a diagnosis of definite AD plus nigral Lewy bodies. Gender, apolipoprotein E (APOE) genotype, brain weight, age at death, duration of disease and Braak stage were compared between the two groups. Statistical analyses were performed using Fisher's exact test for comparisons of categorical data and Student's t-test for comparison of means for continuous outcomes. The proportion of males and females was balanced in the combined AD and DLB populations. There was a highly statistically significant increased frequency of APOE 3/4 in males with DLB (P = 0.007). We found higher brain weights in males with DLB versus males with AD (P = 0.012). AD was more frequent in females and DLB was more frequent in males (P = 0.019). Our findings with respect to age at death, duration of disease and Braak stage within diagnostic groups confirm previously reported findings. These data suggest that Lewy bodies are more common in males affected with dementia, especially those with the APOE 3/4 genotype.
Authors:
C K Rosenberg; T J Cummings; A M Saunders; C Widico; L M McIntyre; C M Hulette
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta neuropathologica     Volume:  102     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-13     Completed Date:  2002-05-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  621-6     Citation Subset:  IM    
Affiliation:
Bryan Alzheimer's Disease Research Center, Department of Medicine, Division of Neurology, Box 2900, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Aged, 80 and over
Alzheimer Disease / genetics,  pathology*
Apolipoproteins E / genetics*
Brain / pathology*,  physiopathology
Female
Genetic Testing
Genotype
Humans
Lewy Body Disease / genetics,  pathology*
Male
Neurons / pathology
Retrospective Studies
Sex Factors
Grant Support
ID/Acronym/Agency:
P50 AG05128/AG/NIA NIH HHS; P50, NS 39764/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins E

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