Document Detail

Dementia patients with low serum cobalamin concentration: relationship to atrophic gastritis.
MedLine Citation:
PMID:  1627675     Owner:  NLM     Status:  MEDLINE    
Serum concentrations of group I pepsinogens (pepsinogen-I) and gastrin were determined in patients with dementia disorders in order to assess the relationship, if any, between these indices of gastric mucosal function and serum cobalamin (vitamin B12) levels. A significant positive correlation between pepsinogen-I and B12 and, as expected, an inverse relationship between gastrin and pepsinogen-I concentrations was found, indicating that vitamin B12 deficiency was mainly determined by gastric mucosal atrophy (atrophic gastritis) in this West-Swedish sample of patients with dementia disorders. Patients with low B12 but normal gastrin and pepsinogen-I concentrations should, therefore, be further evaluated for possible nutritional deficiency, as well as nongastric causes of poor B12 assimilation from the diet.
B Regland; C G Gottfries; G Lindstedt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Aging (Milan, Italy)     Volume:  4     ISSN:  0394-9532     ISO Abbreviation:  Aging (Milano)     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-08-14     Completed Date:  1992-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102503     Medline TA:  Aging (Milano)     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
Department of Psychiatry and Neurochemistry, St. Jörgen Hospital, Göteborg, Sweden.
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MeSH Terms
Aged, 80 and over
Dementia / blood,  complications*,  etiology
Gastric Mucosa / metabolism
Gastrins / blood
Gastritis, Atrophic / blood,  complications*
Intestinal Absorption
Pepsinogens / blood
Vitamin B 12 / blood,  pharmacokinetics
Vitamin B 12 Deficiency / blood,  complications*,  etiology
Reg. No./Substance:
0/Gastrins; 0/Pepsinogens; 68-19-9/Vitamin B 12

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