| Dementia associated with lacunar infarction. | |
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MedLine Citation:
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PMID: 1519275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: The purpose of this study was to assess the number of patients with lacunar lesions who develop dementia and to evaluate in patients with and without dementia the relevance of risk factors for cerebrovascular disease, the occurrence of leukoaraiosis, the volume and location of vascular lesions, the size of ventricular and subarachnoid spaces, and stroke recurrence. METHODS: One hundred eight patients in whom computed tomograms revealed lacunar lesions that could account for their clinical neurological pictures were followed up for an average of 4 years after their first lacunar stroke. RESULTS: Twenty-five patients (23.1%) developed dementia. The prognosis regarding occurrence of dementia during the follow-up period, evaluated by the Kaplan-Meier method, was significantly worse in subjects with the greatest evidence of cerebral atrophy (p less than 0.009) and in subjects who underwent new focal cerebrovascular episodes (p less than 0.000001). No differences were seen in the frequency of vascular risk factors or the site or volume of lesions between the demented and nondemented groups. CONCLUSIONS: Patients with lacunar infarcts suffer from dementia 4-12 times more frequently than the normal population. Cerebral atrophy and recurrent stroke, as well as other as-yet unclarified factors, are involved in producing dementia. |
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Authors:
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C Loeb; C Gandolfo; R Croce; M Conti |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 23 ISSN: 0039-2499 ISO Abbreviation: Stroke Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-10-06 Completed Date: 1992-10-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1225-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Genova, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Brain / radiography Cerebral Infarction / complications* Cerebral Ventriculography Cerebrovascular Disorders / etiology Dementia / complications* Female Humans Longitudinal Studies Male Middle Aged Recurrence Risk Factors Subarachnoid Space / radiography Tomography, X-Ray Computed |
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