Document Detail

Demand for sucrose in the genetically obese Zucker (fa/fa) rat.
MedLine Citation:
PMID:  20674704     Owner:  NLM     Status:  MEDLINE    
Obese Zucker rats (fa/fa) eat more food than lean controls in free-feeding conditions, which strongly influences their phenotypic expression. Few studies, however, characterize their food consumption in environments that are more representative of foraging conditions, e.g., how effort plays a role in food procurement. This study examined the reinforcing efficacy of sucrose in obese Zucker rats by varying the responses required to obtain single sucrose pellets. Male Zucker rats (15 lean, 14 obese) lever-pressed under eight fixed ratio (FR) schedules of sucrose reinforcement, in which the number of lever-presses required to gain access to a single sucrose pellet varied from 1 to 300. Linear and exponential demand equations, which characterize the value of a reinforcer by its sensitivity to price (FR), were fit to the number of food reinforcers and responses made. Free food consumption was also examined. Obese Zuckers, compared to leans, consumed more food under free-feeding conditions. Moreover, they had higher levels of consumption and response output, but only at low FR values. Both groups were equally sensitive to price increases at higher FR values. This suggests that environmental conditions may interact with genes in the expression of food reinforcer efficacy.
Erin B Rasmussen; William Reilly; Conrad Hillman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-07-30
Journal Detail:
Title:  Behavioural processes     Volume:  85     ISSN:  1872-8308     ISO Abbreviation:  Behav. Processes     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703854     Medline TA:  Behav Processes     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  191-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier B.V. All rights reserved.
Idaho State University, Department of Psychology, Mail Stop 8112, Pocatello, ID 83209-8112, United States.
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MeSH Terms
Body Weight
Conditioning, Operant / drug effects
Eating / physiology
Feeding Behavior
Linear Models
Models, Psychological
Obesity / genetics*,  psychology*
Rats, Zucker
Reinforcement (Psychology)
Reinforcement Schedule
Sucrose / pharmacology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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