Document Detail

Demand-specific alteration of medial prefrontal cortex response during an inhibition task in recovered anorexic women.
MedLine Citation:
PMID:  20127942     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: It is well known that individuals with anorexia nervosa (AN) are inhibited and over-controlled. This study investigated a prefrontal-cingulate network that is involved in inhibitory control.
METHOD: To avoid the confounds of malnutrition, 12 recovered (RAN) subjects were compared to 12 matched control women (CW) using a validated inhibition task (i.e., a stop signal task) during functional magnetic resonance imaging.
RESULTS: Consistent with the a priori hypothesis, RAN subjects showed altered task-related activation in the medial prefrontal cortex (mPFC), a critical node of the inhibitory control network. Specifically, whereas RAN and CW showed similar mPFC acitivity during trials when inhibitory demand was low (i.e., easy trials), RAN relative to CW showed significantly less mPFC activation as inhibition trials became more difficult (i.e., hard trials), suggesting a demand-specific modulation of inhibitory control circuitry in RAN.
DISCUSSION: These findings support a neural basis for altered impulse control symptoms in AN © © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:1-8).
Tyson A Oberndorfer; Walter H Kaye; Alan N Simmons; Irina A Strigo; Scott C Matthews
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of eating disorders     Volume:  44     ISSN:  1098-108X     ISO Abbreviation:  Int J Eat Disord     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8111226     Medline TA:  Int J Eat Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley Periodicals, Inc.
Department of Psychiatry, University of California San Diego, La Jolla, California; Eating Disorders Program, University of California San Diego, La Jolla, California.
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