Document Detail

Delusions and dorso-medial frontal cortex volume in first-episode schizophrenia: a voxel-based morphometry study.
MedLine Citation:
PMID:  19395244     Owner:  NLM     Status:  MEDLINE    
Of the few studies that have directly investigated the neuroanatomical correlates of delusions in patients with recent-onset schizophrenia, a number have paradoxically reported a positive correlation between delusion severity and regional grey matter volume. In order to explore this relationship, 31 patients with first-episode schizophrenia (FES) underwent a clinical interview and a T1-weighted structural MRI scan. Patients' scores on the Delusions subscale of the Positive and Negative Syndrome Scale were correlated with the volume of every voxel in their grey matter images in SPM99. Patients' delusion scores were found to correlate with the volume of a cluster of voxels located in the dorso-medial frontal cortex, centred on the medial frontal gyrus. Post-hoc analysis revealed that this 'region-of-correlation' was volumetrically reduced in the FES patients relative to a group of 21 matched healthy controls. The results of this study support the hypothesis that while a certain level of structural brain atrophy is necessary for delusion formation in patients with FES, excessive structural atrophy may in fact preclude the formation of highly systematized delusions.
Thomas J Whitford; Tom F D Farrow; Leanne M Williams; Lavier Gomes; John Brennan; Anthony W F Harris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-22
Journal Detail:
Title:  Psychiatry research     Volume:  172     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  IM    
The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead, NSW, 2145, Australia. <>
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MeSH Terms
Analysis of Variance
Case-Control Studies
Delusions / pathology*,  psychology*
Frontal Lobe / pathology*
Functional Laterality
Image Processing, Computer-Assisted
Magnetic Resonance Imaging*
Psychiatric Status Rating Scales
Schizophrenia / diagnosis,  pathology*
Schizophrenic Psychology*
Time Factors
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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