| Deltaran prevents an adverse effect of emotional stress on the course of cerebral ischemia in low-resistant animals. | |
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MedLine Citation:
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PMID: 17181053 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Local cerebral blood flow in the left hemisphere decreased most significantly in low-resistant Wistar rats preexposed to emotional stress. Deltaran selectively increased blood flow in the left hemisphere and improved blood supply to neuronal activity unit of the brain in these animals. This drug prevented progressive decrease in local cerebral blood flow in both hemispheres during the acute stage of ischemia. The effect of Deltaran was related to modulation of collateral blood flow and adequate blood supply to neuronal activity unit in the brain tissue. Deltaran decreased the mortality rate (by 62%) and alleviated the symptoms of cerebral ischemia. The positive effect of Deltaran was more pronounced in the left hemisphere. |
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Authors:
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I L Konorova; I V Gannushkina; E V Koplik; A L Antelava |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 141 ISSN: 0007-4888 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-12-21 Completed Date: 2007-02-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 564-6 Citation Subset: IM |
Affiliation:
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Institute of Neurology, Russian Academy of Medical Sciences, Moscow. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Ischemia / mortality, pathology* Delta Sleep-Inducing Peptide / pharmacology, therapeutic use* Drug Combinations Electroencephalography Glycine / pharmacology, therapeutic use* Male Rats Rats, Wistar Regional Blood Flow / drug effects Stress, Psychological / drug therapy*, physiopathology* Telencephalon / blood supply* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/deltaran; 56-40-6/Glycine; 69431-45-4/Delta Sleep-Inducing Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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