| Delta9-tetrahydrocannabinol increases C6 glioma cell death produced by oxidative stress. | |
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MedLine Citation:
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PMID: 15975726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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(-)Delta9-tetrahydrocannabinol is a scavenger of free radicals. However, the activation of the CB1 receptor in cultured C6 glioma cells by (-)delta9-tetrahydrocannabinol in the presence of reagents generating reactive oxygen species leads to amplification of the cellular damage from oxidative stress. This was evident by increased loss of cell wall integrity, impaired mitochondrial function and reduction of glucose uptake. In addition, (-)delta9-tetrahydrocannabinol treatment was also found to be deleterious to the cells under conditions of glucose starvation. Free radicals have been implicated in various conditions leading to cell death and, as a routine, the Fenton reaction is utilized for modeling reactive oxygen species production. Our study was performed using a cell permeating Fe(III) chelating quinone that provides more physiological conditions for mimicking the naturally occurring oxidative stress within the cell and thus serves as a better model for natural reactive oxygen species formation. |
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Authors:
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I Goncharov; L Weiner; Z Vogel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience Volume: 134 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 2005 |
Date Detail:
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Created Date: 2005-08-08 Completed Date: 2005-11-15 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 567-74 Citation Subset: IM |
Affiliation:
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Department of Neurobiology, Weizmann Institute of Science, Herzel Street, Rehovot 76100, Israel. igor.goncharov@weizmann.ac.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport CHO Cells Cell Death / drug effects* Cell Line, Tumor Cell Survival / drug effects Cricetinae Deoxyglucose / pharmacokinetics Glioma / pathology* Hela Cells Humans Oxidative Stress / physiology* Receptor, Cannabinoid, CB1 / drug effects, physiology Tetrahydrocannabinol / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Cannabinoid, CB1; 154-17-6/Deoxyglucose; 1972-08-3/Tetrahydrocannabinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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